Indirect fluorometric determination of diclofenac sodium

A simple and easy method of analysis for diclofenac sodium is reported. A spectrofluorometric method for the microdetermination of diclofenac sodium has been developed through its reaction with cerium(IV) in an acidic solution and measurement of the fluorescence of the Ce(III) ions produced. Under t...

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Detalles Bibliográficos
Autores principales: Castillo, Marcela A., Bruzzone, Liliana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2006
Materias:
Química
Diclofenaco
Espectrometría de Fluorescencia
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83452
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83452
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Diclofenaco
Espectrometría de Fluorescencia
spellingShingle Química
Diclofenaco
Espectrometría de Fluorescencia
Castillo, Marcela A.
Bruzzone, Liliana
Indirect fluorometric determination of diclofenac sodium
topic_facet Química
Diclofenaco
Espectrometría de Fluorescencia
description A simple and easy method of analysis for diclofenac sodium is reported. A spectrofluorometric method for the microdetermination of diclofenac sodium has been developed through its reaction with cerium(IV) in an acidic solution and measurement of the fluorescence of the Ce(III) ions produced. Under the optimum experimental conditions for the oxidation reaction, 1.0 M H 2 SO 4 with 90 min of heating time (100°C), the range of application is 124.3 - 600 ng mL -1 and the limit of detection is 72.7 ng mL -1 . The proposed method was applied to the determination of diclofenac sodium in pharmaceutical tablets. The results of the analysis show a good agreement with those obtained by the official USP 27 HPLC method.
format Articulo
Articulo
author Castillo, Marcela A.
Bruzzone, Liliana
author_facet Castillo, Marcela A.
Bruzzone, Liliana
author_sort Castillo, Marcela A.
title Indirect fluorometric determination of diclofenac sodium
title_short Indirect fluorometric determination of diclofenac sodium
title_full Indirect fluorometric determination of diclofenac sodium
title_fullStr Indirect fluorometric determination of diclofenac sodium
title_full_unstemmed Indirect fluorometric determination of diclofenac sodium
title_sort indirect fluorometric determination of diclofenac sodium
publishDate 2006
url http://sedici.unlp.edu.ar/handle/10915/83452
work_keys_str_mv AT castillomarcelaa indirectfluorometricdeterminationofdiclofenacsodium
AT bruzzoneliliana indirectfluorometricdeterminationofdiclofenacsodium
bdutipo_str Repositorios
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