Optimization and pharmacodynamic evaluation of solid dispersion of gliclazide for dissolution rate enhancement

The present study utilizes approach of solid dispersions (SDs) to improve dissolution rate of Gliclazide (GLZ); a poorly water soluble anti-diabetic drug. Formulations were prepared by solvent evaporation and melt dispersion techniques using poloxamer as hydrophilic carriers. SDs and physical mixtur...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Thorat, Yogesh S., Hosmani, Avinash H.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
anti-diabetic activity; dissolution; gliclazide; poloxamer; solid dispersion; solubility enhancement
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8343
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_21.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8343
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
anti-diabetic activity; dissolution; gliclazide; poloxamer; solid dispersion; solubility enhancement
spellingShingle Farmacia
anti-diabetic activity; dissolution; gliclazide; poloxamer; solid dispersion; solubility enhancement
Thorat, Yogesh S.
Hosmani, Avinash H.
Optimization and pharmacodynamic evaluation of solid dispersion of gliclazide for dissolution rate enhancement
topic_facet Farmacia
anti-diabetic activity; dissolution; gliclazide; poloxamer; solid dispersion; solubility enhancement
description The present study utilizes approach of solid dispersions (SDs) to improve dissolution rate of Gliclazide (GLZ); a poorly water soluble anti-diabetic drug. Formulations were prepared by solvent evaporation and melt dispersion techniques using poloxamer as hydrophilic carriers. SDs and physical mixtures (PM) were characterized by thin layer chomatography, FTIR spectroscopy, X-Ray Diffractometry, and Differential Scanning Calorimetry. TLC was used to identify any possibility of degradation during preparation and optimize melting temperature for melt dispersion batches, which was supported by FTIR and DSC, showing absence of chemical interaction between the drug and carrier. XRD showed that GLZ was converted to amorphous form. Enhancement in dissolution was found more prominent with melt dispersions compared to solvent evaporation and physical mixtures. In vivo pharmacodynamic bioavailability study was performed for 28 days on alloxan induced diabetic wistar rats. Blood glucose levels were evidently lowered and controlled by SD compared to GLZ alone.
format Articulo
Articulo
author Thorat, Yogesh S.
Hosmani, Avinash H.
author_facet Thorat, Yogesh S.
Hosmani, Avinash H.
author_sort Thorat, Yogesh S.
title Optimization and pharmacodynamic evaluation of solid dispersion of gliclazide for dissolution rate enhancement
title_short Optimization and pharmacodynamic evaluation of solid dispersion of gliclazide for dissolution rate enhancement
title_full Optimization and pharmacodynamic evaluation of solid dispersion of gliclazide for dissolution rate enhancement
title_fullStr Optimization and pharmacodynamic evaluation of solid dispersion of gliclazide for dissolution rate enhancement
title_full_unstemmed Optimization and pharmacodynamic evaluation of solid dispersion of gliclazide for dissolution rate enhancement
title_sort optimization and pharmacodynamic evaluation of solid dispersion of gliclazide for dissolution rate enhancement
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8343
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_21.pdf
work_keys_str_mv AT thoratyogeshs optimizationandpharmacodynamicevaluationofsoliddispersionofgliclazidefordissolutionrateenhancement
AT hosmaniavinashh optimizationandpharmacodynamicevaluationofsoliddispersionofgliclazidefordissolutionrateenhancement
bdutipo_str Repositorios
_version_ 1764820488609071109

Ejemplares similares