Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics

The oral bioavailability of genistein (GE) in its benzensulfonates was studied in search for new drugs or food functional ingredients. The plasma were collected at different points of time after the intragastric or intravenous administration of genistein benzensulfonate (GBS) 40 mg/kg to rats. The G...

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Autores principales: Fan, Yaw-ei, Li, Jing, Liu, Rong, Ye, Zhi-Gang, Hu, Jiang-ning, Deng, Ze-yuan, Peng, You
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8342
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_20.pdf
Aporte de:
id I19-R120-10915-8342
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
bioavailability; genistein; pharmacokinetics; progrug; sulfonate
spellingShingle Farmacia
bioavailability; genistein; pharmacokinetics; progrug; sulfonate
Fan, Yaw-ei
Li, Jing
Liu, Rong
Ye, Zhi-Gang
Hu, Jiang-ning
Deng, Ze-yuan
Peng, You
Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics
topic_facet Farmacia
bioavailability; genistein; pharmacokinetics; progrug; sulfonate
description The oral bioavailability of genistein (GE) in its benzensulfonates was studied in search for new drugs or food functional ingredients. The plasma were collected at different points of time after the intragastric or intravenous administration of genistein benzensulfonate (GBS) 40 mg/kg to rats. The GBS and GE contents in plasma were determined by HPLC. The compartment model was fitted and pharmacokinetic parameters were calculated by DAS 2.1.1. The result indicated that the dynamic process of GE was consistent with two compartment model after intragastric or intravenous administration of two GBS prodrugs to rats. The relative oral bioavailability of GE in two prodrugs GBS1 and GBS2 were 159.2 and 253.8 %, respectively. In conclusion, the above results demonstrated that the oral bioavailability of GE in two prodrugs had been improved. Meanwhile, GBS2 was proven to have a higher relative bioavailability prodrug of GE than GBS1.
format Articulo
Articulo
author Fan, Yaw-ei
Li, Jing
Liu, Rong
Ye, Zhi-Gang
Hu, Jiang-ning
Deng, Ze-yuan
Peng, You
author_facet Fan, Yaw-ei
Li, Jing
Liu, Rong
Ye, Zhi-Gang
Hu, Jiang-ning
Deng, Ze-yuan
Peng, You
author_sort Fan, Yaw-ei
title Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics
title_short Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics
title_full Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics
title_fullStr Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics
title_full_unstemmed Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics
title_sort oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8342
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_20.pdf
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