Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics
The oral bioavailability of genistein (GE) in its benzensulfonates was studied in search for new drugs or food functional ingredients. The plasma were collected at different points of time after the intragastric or intravenous administration of genistein benzensulfonate (GBS) 40 mg/kg to rats. The G...
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Autores principales: | , , , , , , |
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Formato: | Articulo |
Lenguaje: | Inglés |
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2011
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8342 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_20.pdf |
Aporte de: |
id |
I19-R120-10915-8342 |
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record_format |
dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Farmacia bioavailability; genistein; pharmacokinetics; progrug; sulfonate |
spellingShingle |
Farmacia bioavailability; genistein; pharmacokinetics; progrug; sulfonate Fan, Yaw-ei Li, Jing Liu, Rong Ye, Zhi-Gang Hu, Jiang-ning Deng, Ze-yuan Peng, You Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics |
topic_facet |
Farmacia bioavailability; genistein; pharmacokinetics; progrug; sulfonate |
description |
The oral bioavailability of genistein (GE) in its benzensulfonates was studied in search for new drugs or food functional ingredients. The plasma were collected at different points of time after the intragastric or intravenous administration of genistein benzensulfonate (GBS) 40 mg/kg to rats. The GBS and GE contents in plasma were determined by HPLC. The compartment model was fitted and pharmacokinetic parameters were calculated by DAS 2.1.1. The result indicated that the dynamic process of GE was consistent with two compartment model after intragastric or intravenous administration of two GBS prodrugs to rats. The relative oral bioavailability of GE in two prodrugs GBS1 and GBS2 were 159.2 and 253.8 %, respectively. In conclusion, the above results demonstrated that the oral bioavailability of GE in two prodrugs had been improved. Meanwhile, GBS2 was proven to have a higher relative bioavailability prodrug of GE than GBS1. |
format |
Articulo Articulo |
author |
Fan, Yaw-ei Li, Jing Liu, Rong Ye, Zhi-Gang Hu, Jiang-ning Deng, Ze-yuan Peng, You |
author_facet |
Fan, Yaw-ei Li, Jing Liu, Rong Ye, Zhi-Gang Hu, Jiang-ning Deng, Ze-yuan Peng, You |
author_sort |
Fan, Yaw-ei |
title |
Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics |
title_short |
Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics |
title_full |
Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics |
title_fullStr |
Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics |
title_full_unstemmed |
Oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics |
title_sort |
oral bioavailability of novel genistein sulfonates and their pre-clinical pharmacokinetics |
publishDate |
2011 |
url |
http://sedici.unlp.edu.ar/handle/10915/8342 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_20.pdf |
work_keys_str_mv |
AT fanyawei oralbioavailabilityofnovelgenisteinsulfonatesandtheirpreclinicalpharmacokinetics AT lijing oralbioavailabilityofnovelgenisteinsulfonatesandtheirpreclinicalpharmacokinetics AT liurong oralbioavailabilityofnovelgenisteinsulfonatesandtheirpreclinicalpharmacokinetics AT yezhigang oralbioavailabilityofnovelgenisteinsulfonatesandtheirpreclinicalpharmacokinetics AT hujiangning oralbioavailabilityofnovelgenisteinsulfonatesandtheirpreclinicalpharmacokinetics AT dengzeyuan oralbioavailabilityofnovelgenisteinsulfonatesandtheirpreclinicalpharmacokinetics AT pengyou oralbioavailabilityofnovelgenisteinsulfonatesandtheirpreclinicalpharmacokinetics |
bdutipo_str |
Repositorios |
_version_ |
1764820488593342469 |