Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats

We analyzed the effect of oral administration of cyclosporine- methylprednisone (CsA-MP) and sirolimus (SRL) on the lipid pattern of kidney-transplanted rats after a 7-day survival. A significant increase in plasma cholesterol in CsA-MP group (control: 26 ± 3 mg/dl vs. 59 ± 8 mg/dl, P < 0.05) and...

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Autores principales: Lausada, Natalia Raquel, Tacconi de Gómez Dumm, Irma Nelva, Luna, Georgina Cecilia, Camihort, Gisela, Raimondi, J. Clemente
Formato: Articulo
Lenguaje:Inglés
Publicado: 2005
Materias:
Ciencias Médicas
Cholesterol
Cydosporine
Polyunsaturated fatty acids
Prednisone
Sirolimus
Triglycerides
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83413
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83413
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Cholesterol
Cydosporine
Polyunsaturated fatty acids
Prednisone
Sirolimus
Triglycerides
spellingShingle Ciencias Médicas
Cholesterol
Cydosporine
Polyunsaturated fatty acids
Prednisone
Sirolimus
Triglycerides
Lausada, Natalia Raquel
Tacconi de Gómez Dumm, Irma Nelva
Luna, Georgina Cecilia
Camihort, Gisela
Raimondi, J. Clemente
Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
topic_facet Ciencias Médicas
Cholesterol
Cydosporine
Polyunsaturated fatty acids
Prednisone
Sirolimus
Triglycerides
description We analyzed the effect of oral administration of cyclosporine- methylprednisone (CsA-MP) and sirolimus (SRL) on the lipid pattern of kidney-transplanted rats after a 7-day survival. A significant increase in plasma cholesterol in CsA-MP group (control: 26 ± 3 mg/dl vs. 59 ± 8 mg/dl, P < 0.05) and in triglyceride levels in SRL group (control: 53 ± 4 mg/dl vs. 114 ± 3 mg/dl, P < 0.05), was shown. Kidney microsomal membranes from both treated groups showed that cholesterol and triglyceride values and the relative percentage of arachidonic acid in the total amount of n-6 fatty acids decreased. A diminution of linoleic acid occurred in testis (control: 9.4 ± 0.1 mg/dl vs. CsA-MP: 6.0 ± 0.3 mg/dl and vs. SRL: 6.8 ± 0.2 mg/dl, P < 0.05), liver (control: 17.7 ± 0.6 mg/dl vs. CsA-MP: 15.1 ± 0.6 mg/dl and SRL: 13.5 ± 0.8 mg/dl, P < 0.05) and erythrocyte membranes (control:11.7 ± 0.1% vs. CsA-MP: 10.6 ± 0.2% and SRL: 10.0 ± 0.4%, P < 0.01). The immunosuppressive therapies improved the rejection rate of the graft, fact that was remarkable in the SRL-treated group. However, lipid abnormalities still remain in spite of immunosuppressive therapies. (150).
format Articulo
Articulo
author Lausada, Natalia Raquel
Tacconi de Gómez Dumm, Irma Nelva
Luna, Georgina Cecilia
Camihort, Gisela
Raimondi, J. Clemente
author_facet Lausada, Natalia Raquel
Tacconi de Gómez Dumm, Irma Nelva
Luna, Georgina Cecilia
Camihort, Gisela
Raimondi, J. Clemente
author_sort Lausada, Natalia Raquel
title Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
title_short Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
title_full Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
title_fullStr Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
title_full_unstemmed Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
title_sort effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
publishDate 2005
url http://sedici.unlp.edu.ar/handle/10915/83413
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bdutipo_str Repositorios
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