Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages

Mostrar todas las versiones(3)

There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubert...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: França, L. R., Suescun, M. O., Miranda, J. R., Giovambattista, Andrés, Perelló, Mario, Spinedi, Eduardo, Calandra, Ricardo Saúl
Formato: Articulo
Lenguaje:Inglés
Publicado: 2005
Materias:
Biología
Ciencias Exactas
monosodium L-glutamate
testis structure
testis function
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83357
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83357
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Ciencias Exactas
monosodium L-glutamate
testis structure
testis function
spellingShingle Biología
Ciencias Exactas
monosodium L-glutamate
testis structure
testis function
França, L. R.
Suescun, M. O.
Miranda, J. R.
Giovambattista, Andrés
Perelló, Mario
Spinedi, Eduardo
Calandra, Ricardo Saúl
Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages
topic_facet Biología
Ciencias Exactas
monosodium L-glutamate
testis structure
testis function
description There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubertal and adult ages. Plasma levels of leptin, LH, FSH, prolactin, testosterone (T), corticosterone, and free T4 (FT4) were measured. MSG rats displayed elevated circulating levels of corticosterone and hyperadiposity/ hyperleptinemia, regardless of the age examined; conversely, circulating prolactin levels were not affected. Moreover, prepubertal MSG rats revealed a significant (P < 0.05) reduction in testis weight and the number of Sertoli (SC) and Leydig cells per testis. Leptin plasma levels were severalfold higher (2.41 vs. 8.07; P < 0.05) in prepubertal MSG rats, and these animals displayed plasma LH, FSH, T, and FT4 levels significantly decreased (P < 0.05). Taken together, these data indicate that testis development, as well as SC and Leydig cell proliferation, were disturbed in prepubertal MSG rats. Adult MSG rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04; P < 0.05) and lower (P < 0.05) LH and FSH plasma levels. However, T and FT4 plasma levels were normal, and no apparent alterations were observed in testis structure of MSG rats. Only the number of SCs per testis was significantly (P < 0.05) reduced in the adult MSG rats. In conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably responsible for the reproductive axis damages in MSG animals, it remains to be investigated whether this condition is the main factor for hypothalamus-pituitary-gonadal axis dysfunction in MSG rats.
format Articulo
Articulo
author França, L. R.
Suescun, M. O.
Miranda, J. R.
Giovambattista, Andrés
Perelló, Mario
Spinedi, Eduardo
Calandra, Ricardo Saúl
author_facet França, L. R.
Suescun, M. O.
Miranda, J. R.
Giovambattista, Andrés
Perelló, Mario
Spinedi, Eduardo
Calandra, Ricardo Saúl
author_sort França, L. R.
title Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages
title_short Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages
title_full Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages
title_fullStr Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages
title_full_unstemmed Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages
title_sort testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages
publishDate 2005
url http://sedici.unlp.edu.ar/handle/10915/83357
work_keys_str_mv AT francalr testisstructureandfunctioninanongenetichyperadiposeratmodelatprepubertalandadultages
AT suescunmo testisstructureandfunctioninanongenetichyperadiposeratmodelatprepubertalandadultages
AT mirandajr testisstructureandfunctioninanongenetichyperadiposeratmodelatprepubertalandadultages
AT giovambattistaandres testisstructureandfunctioninanongenetichyperadiposeratmodelatprepubertalandadultages
AT perellomario testisstructureandfunctioninanongenetichyperadiposeratmodelatprepubertalandadultages
AT spinedieduardo testisstructureandfunctioninanongenetichyperadiposeratmodelatprepubertalandadultages
AT calandraricardosaul testisstructureandfunctioninanongenetichyperadiposeratmodelatprepubertalandadultages
bdutipo_str Repositorios
_version_ 1764820488536719363

Ejemplares similares