Tissue distribution and pharmacokinetics of vitexin-2"-O-rhamnoside in mice after oral and intravenous administration
The aim of the study was to characterize the preclinical pharmacokinetics and comparative pharmacokinetics of pure vitexin-2"-O-rhamnoside (VR) in mice after oral and intravenous administration at dose of 30 mg/kg. A sensitive and specific HPLC method with internal standard was developed and va...
Guardado en:
| Autores principales: | , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8332 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_10.pdf |
| Aporte de: |
| id |
I19-R120-10915-8332 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia HPLC; pharmacokinetics; tissue distribution; vitexin-2"-O-rhamnoside Flavonoides Vías de Administración de Medicamentos |
| spellingShingle |
Farmacia HPLC; pharmacokinetics; tissue distribution; vitexin-2"-O-rhamnoside Flavonoides Vías de Administración de Medicamentos Du, Yang Wang, Fei Wang, Dong Li, Hai-bo Zhang, Wen-jie Cheng, Zhong-zhe Ying, Xi-xiang Kang, Ting-guo Tissue distribution and pharmacokinetics of vitexin-2"-O-rhamnoside in mice after oral and intravenous administration |
| topic_facet |
Farmacia HPLC; pharmacokinetics; tissue distribution; vitexin-2"-O-rhamnoside Flavonoides Vías de Administración de Medicamentos |
| description |
The aim of the study was to characterize the preclinical pharmacokinetics and comparative pharmacokinetics of pure vitexin-2"-O-rhamnoside (VR) in mice after oral and intravenous administration at dose of 30 mg/kg. A sensitive and specific HPLC method with internal standard was developed and validated for the pharmacokinetic studies of VR. The results showed that VR was rapidly and widespreadly distributed throughout the whole body after administration and the oral bioavailability of VR was 4.89 %. The highest VR level after intravenous dosing was obtained in gallbladder, followed by liver, intestine, kidney, stomach, lung, heart, spleen and muscle. While, the highest VR level after oral route was observed in intestine, followed by stomach, gallbladder, liver, heart, kidney and muscle. |
| format |
Articulo Articulo |
| author |
Du, Yang Wang, Fei Wang, Dong Li, Hai-bo Zhang, Wen-jie Cheng, Zhong-zhe Ying, Xi-xiang Kang, Ting-guo |
| author_facet |
Du, Yang Wang, Fei Wang, Dong Li, Hai-bo Zhang, Wen-jie Cheng, Zhong-zhe Ying, Xi-xiang Kang, Ting-guo |
| author_sort |
Du, Yang |
| title |
Tissue distribution and pharmacokinetics of vitexin-2"-O-rhamnoside in mice after oral and intravenous administration |
| title_short |
Tissue distribution and pharmacokinetics of vitexin-2"-O-rhamnoside in mice after oral and intravenous administration |
| title_full |
Tissue distribution and pharmacokinetics of vitexin-2"-O-rhamnoside in mice after oral and intravenous administration |
| title_fullStr |
Tissue distribution and pharmacokinetics of vitexin-2"-O-rhamnoside in mice after oral and intravenous administration |
| title_full_unstemmed |
Tissue distribution and pharmacokinetics of vitexin-2"-O-rhamnoside in mice after oral and intravenous administration |
| title_sort |
tissue distribution and pharmacokinetics of vitexin-2"-o-rhamnoside in mice after oral and intravenous administration |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8332 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_10.pdf |
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Repositorios |
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