Preparation and evaluation of modified release zidovudine tablets

Zidovudine is a drug used for the treatment of AIDS. The objective of this work was to prepare tablets for modified release of zidovudine. Hydroxypropyl methylcellulose HPMC K100LV and HPMC K4M at 12.50 %, 18.75 % and 25.00 % were used. The tablets produced with 12.50 % of HPMC reached 100 % of the...

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Detalles Bibliográficos
Autores principales: Bicheri, María T. L., Chaud, Marco Vinicius, Gonçalves, Marcos M., Vila, Marta M. D. C.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
hydroxypropyl methylcellulose; modified release; zidovudine
Timidina
Sistemas de Liberación de Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8331
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_9.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8331
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
hydroxypropyl methylcellulose; modified release; zidovudine
Timidina
Sistemas de Liberación de Medicamentos
spellingShingle Farmacia
hydroxypropyl methylcellulose; modified release; zidovudine
Timidina
Sistemas de Liberación de Medicamentos
Bicheri, María T. L.
Chaud, Marco Vinicius
Gonçalves, Marcos M.
Vila, Marta M. D. C.
Preparation and evaluation of modified release zidovudine tablets
topic_facet Farmacia
hydroxypropyl methylcellulose; modified release; zidovudine
Timidina
Sistemas de Liberación de Medicamentos
description Zidovudine is a drug used for the treatment of AIDS. The objective of this work was to prepare tablets for modified release of zidovudine. Hydroxypropyl methylcellulose HPMC K100LV and HPMC K4M at 12.50 %, 18.75 % and 25.00 % were used. The tablets produced with 12.50 % of HPMC reached 100 % of the zidovudine release in 6 hours, while those produced with 18.75 and 25.00 %, released 24 h, following the Higuchi and First Order kinetic models, respectively. The calculated release exponent pointed out that formulations follow the anomalous type of release mechanism, with a combined phenomena of diffusion and erosion.
format Articulo
Articulo
author Bicheri, María T. L.
Chaud, Marco Vinicius
Gonçalves, Marcos M.
Vila, Marta M. D. C.
author_facet Bicheri, María T. L.
Chaud, Marco Vinicius
Gonçalves, Marcos M.
Vila, Marta M. D. C.
author_sort Bicheri, María T. L.
title Preparation and evaluation of modified release zidovudine tablets
title_short Preparation and evaluation of modified release zidovudine tablets
title_full Preparation and evaluation of modified release zidovudine tablets
title_fullStr Preparation and evaluation of modified release zidovudine tablets
title_full_unstemmed Preparation and evaluation of modified release zidovudine tablets
title_sort preparation and evaluation of modified release zidovudine tablets
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8331
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_9.pdf
work_keys_str_mv AT bicherimariatl preparationandevaluationofmodifiedreleasezidovudinetablets
AT chaudmarcovinicius preparationandevaluationofmodifiedreleasezidovudinetablets
AT goncalvesmarcosm preparationandevaluationofmodifiedreleasezidovudinetablets
AT vilamartamdc preparationandevaluationofmodifiedreleasezidovudinetablets
bdutipo_str Repositorios
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