Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age

Symptomatic hypogammaglobulinaemia in children younger than 2 years of age was studied to rule out a primary immunodeficiency. Thirty-four patients were referred to the Immunology Service to study the hypogammaglobulinaemia- associated clinical picture. Food allergy was documented in 10 patients by...

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Autores principales: Bezrodnik, Liliana, Gómez Raccio, Andrea C., Canil, Laura M., Rey, María Amanda, Carabajal, Patricia C., Fossati, Carlos Alberto, Docena, Guillermo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2007
Materias:
Ciencias Exactas
Antibodies
Cows' milk
Food allergy
Immunodeficiency
Immunoglobulin E
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83297
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83297
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Antibodies
Cows' milk
Food allergy
Immunodeficiency
Immunoglobulin E
spellingShingle Ciencias Exactas
Antibodies
Cows' milk
Food allergy
Immunodeficiency
Immunoglobulin E
Bezrodnik, Liliana
Gómez Raccio, Andrea C.
Canil, Laura M.
Rey, María Amanda
Carabajal, Patricia C.
Fossati, Carlos Alberto
Docena, Guillermo
Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age
topic_facet Ciencias Exactas
Antibodies
Cows' milk
Food allergy
Immunodeficiency
Immunoglobulin E
description Symptomatic hypogammaglobulinaemia in children younger than 2 years of age was studied to rule out a primary immunodeficiency. Thirty-four patients were referred to the Immunology Service to study the hypogammaglobulinaemia- associated clinical picture. Food allergy was documented in 10 patients by personal and familial history, presence of specific immunoglobulin E (IgE) and elevated total serum IgE levels. Coeliac disease and human immunodeficiency virus infection were also ruled out. Protein loss through stools was assessed by clearance of α1-antitrypsin (AAT). Serum immunoglobulin levels were determined by nephelometry and functional antibodies were studied by enzyme-linked immunosorbent assay. The cellular immune response was assessed by in vitro lymphocyte proliferation in response to mitogens and cell subsets were analysed by flow cytometry. In five patients of the 10 patients we suspected a protein loss through the mucosa. Four of these five patients showed an increased AAT and the other showed an extensive cutaneous lesion. Immunological studies revealed normal antibody function, in vitro lymphoproliferative responses and cell numbers in four of the 5 patients. One patient showed abnormally low numbers of CD4+ T cells as well as a defective proliferative response to mitogens. After diagnosis of cow milk allergy, milk was replaced with infant milk formula containing hydrolysed proteins. Recovery of immunoglobulin values and clinical resolution were achieved. Hypogammaglobulinaemia during early childhood in some children may be secondary to cow milk allergy, and immunoglobulins and cells may leak through the inflamed mucosa. Resolution of symptoms as well as normalization of immunoglobulin values may be easily achieved by avoidance of the offending allergen.
format Articulo
Articulo
author Bezrodnik, Liliana
Gómez Raccio, Andrea C.
Canil, Laura M.
Rey, María Amanda
Carabajal, Patricia C.
Fossati, Carlos Alberto
Docena, Guillermo
author_facet Bezrodnik, Liliana
Gómez Raccio, Andrea C.
Canil, Laura M.
Rey, María Amanda
Carabajal, Patricia C.
Fossati, Carlos Alberto
Docena, Guillermo
author_sort Bezrodnik, Liliana
title Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age
title_short Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age
title_full Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age
title_fullStr Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age
title_full_unstemmed Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age
title_sort hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age
publishDate 2007
url http://sedici.unlp.edu.ar/handle/10915/83297
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