Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity

Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central rol...

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Autores principales: Hellwig, Sandra M. M., Rodríguez, María Eugenia, Berbers, Guy A. M., Winkel, Jan G. J. van de, Mooi, Frits R.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2003
Materias:
Ciencias Exactas
Bordetella pertussis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83288
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83288
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Bordetella pertussis
spellingShingle Ciencias Exactas
Bordetella pertussis
Hellwig, Sandra M. M.
Rodríguez, María Eugenia
Berbers, Guy A. M.
Winkel, Jan G. J. van de
Mooi, Frits R.
Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
topic_facet Ciencias Exactas
Bordetella pertussis
description Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity. Opsonophagocytosis was recently found to play a central role in cellular bactericidal activity against B. pertussis. In the present study, we studied the specificity of opsonic antibodies. Anti-pertactin antibodies, but not anti-pertussis toxin, anti-fimbriae, or anti-filamentous hemagglutinin antibodies, were found to be crucial for B. pertussis phagocytosis. These data are consistent with field studies showing that levels of antibodies to pertactin correlate with protection.
format Articulo
Articulo
author Hellwig, Sandra M. M.
Rodríguez, María Eugenia
Berbers, Guy A. M.
Winkel, Jan G. J. van de
Mooi, Frits R.
author_facet Hellwig, Sandra M. M.
Rodríguez, María Eugenia
Berbers, Guy A. M.
Winkel, Jan G. J. van de
Mooi, Frits R.
author_sort Hellwig, Sandra M. M.
title Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
title_short Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
title_full Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
title_fullStr Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
title_full_unstemmed Crucial role of antibodies to pertactin in <i>Bordetella pertussis</i> immunity
title_sort crucial role of antibodies to pertactin in <i>bordetella pertussis</i> immunity
publishDate 2003
url http://sedici.unlp.edu.ar/handle/10915/83288
work_keys_str_mv AT hellwigsandramm crucialroleofantibodiestopertactininibordetellapertussisiimmunity
AT rodriguezmariaeugenia crucialroleofantibodiestopertactininibordetellapertussisiimmunity
AT berbersguyam crucialroleofantibodiestopertactininibordetellapertussisiimmunity
AT winkeljangjvande crucialroleofantibodiestopertactininibordetellapertussisiimmunity
AT mooifritsr crucialroleofantibodiestopertactininibordetellapertussisiimmunity
bdutipo_str Repositorios
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