The deposition of chlorhexidine on chemically modified thermosensitive polyNIPA microgels assessed by EDXS in scanning electron microscopy

The deposition of chlorhexidine base on thermosensitive N-isopropylacrylamide polymeric microparticles was assessed in this study using energy dispersive X-ray spectrometry (EDXS) in scanning electron microscopy (SEM) setting. Three different types of polymer were synthesized. The PN1 was a polymer...

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Autor principal: Musial, Witold
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
chlorhexidine; microgel; N-isopropylacrylamide; thermosensitivity.
Biguanidas
Espectrometría por Rayos X
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8327
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8327
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
chlorhexidine; microgel; N-isopropylacrylamide; thermosensitivity.
Biguanidas
Espectrometría por Rayos X
spellingShingle Farmacia
chlorhexidine; microgel; N-isopropylacrylamide; thermosensitivity.
Biguanidas
Espectrometría por Rayos X
Musial, Witold
The deposition of chlorhexidine on chemically modified thermosensitive polyNIPA microgels assessed by EDXS in scanning electron microscopy
topic_facet Farmacia
chlorhexidine; microgel; N-isopropylacrylamide; thermosensitivity.
Biguanidas
Espectrometría por Rayos X
description The deposition of chlorhexidine base on thermosensitive N-isopropylacrylamide polymeric microparticles was assessed in this study using energy dispersive X-ray spectrometry (EDXS) in scanning electron microscopy (SEM) setting. Three different types of polymer were synthesized. The PN1 was a polymer with terminal anionic groups resulting from potassium persulphate initiator. The PN2 was synthesized with 2,2’-azobis(2-methylpropionamidine)dihydrochloride, what resulted in cationic amidine terminal groups. The PN3 had anionic terminals, however increased hydrophobicity was maintained with Ntert-butylacrylate functional groups. The thermosensitivity of the polymer-chlorhexidine complexes was confirmed by the turbidimetric assay. The deposition patterns, observed in/on the polymers give the assumption to develop the applications of evaluated polymers as factors influencing chlorhexidine release from the topical formulations.
format Articulo
Articulo
author Musial, Witold
author_facet Musial, Witold
author_sort Musial, Witold
title The deposition of chlorhexidine on chemically modified thermosensitive polyNIPA microgels assessed by EDXS in scanning electron microscopy
title_short The deposition of chlorhexidine on chemically modified thermosensitive polyNIPA microgels assessed by EDXS in scanning electron microscopy
title_full The deposition of chlorhexidine on chemically modified thermosensitive polyNIPA microgels assessed by EDXS in scanning electron microscopy
title_fullStr The deposition of chlorhexidine on chemically modified thermosensitive polyNIPA microgels assessed by EDXS in scanning electron microscopy
title_full_unstemmed The deposition of chlorhexidine on chemically modified thermosensitive polyNIPA microgels assessed by EDXS in scanning electron microscopy
title_sort deposition of chlorhexidine on chemically modified thermosensitive polynipa microgels assessed by edxs in scanning electron microscopy
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8327
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_4.pdf
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AT musialwitold depositionofchlorhexidineonchemicallymodifiedthermosensitivepolynipamicrogelsassessedbyedxsinscanningelectronmicroscopy
bdutipo_str Repositorios
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