Lactobacillus johnsonii La1 antagonizes Giardia intestinalis in vivo

This study describes the in vivo activity of Lactobacillus johnsonii La1 (NCC533) in Giardia intestinalis-infected gerbils (Meriones unguiculatus). Daily administration of lactobacilli in the drinking water from 7 days before inoculation with Giardia trophozoites efficiently prevented G. intestinali...

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Detalles Bibliográficos
Autores principales: Humen, Martín Andrés, De Antoni, Graciela Liliana, Benyacoub, Jalil, Costas, María Elena, Cardozo, Marta, Kozubsky, Leonora Eugenia, Saudan, Kim Yen, Boenzli Bruand, Angele, Blum, Stephanie, Schiffrin, Eduardo J., Pérez, Pablo Fernando
Formato: Articulo
Lenguaje:Inglés
Publicado: 2005
Materias:
Ciencias Exactas
Lactobacillus johnsonii
Giardia
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83266
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83266
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Lactobacillus johnsonii
Giardia
spellingShingle Ciencias Exactas
Lactobacillus johnsonii
Giardia
Humen, Martín Andrés
De Antoni, Graciela Liliana
Benyacoub, Jalil
Costas, María Elena
Cardozo, Marta
Kozubsky, Leonora Eugenia
Saudan, Kim Yen
Boenzli Bruand, Angele
Blum, Stephanie
Schiffrin, Eduardo J.
Pérez, Pablo Fernando
Lactobacillus johnsonii La1 antagonizes Giardia intestinalis in vivo
topic_facet Ciencias Exactas
Lactobacillus johnsonii
Giardia
description This study describes the in vivo activity of Lactobacillus johnsonii La1 (NCC533) in Giardia intestinalis-infected gerbils (Meriones unguiculatus). Daily administration of lactobacilli in the drinking water from 7 days before inoculation with Giardia trophozoites efficiently prevented G. intestinalis strain WB clone C6 from infecting gerbils. More specifically, shedding of fecal Giardia antigens (GSA65 protein) was diminished in the La1-treated group, and resolution of infection was observed by 21 days postinoculation. Histology and analysis of enzymatic markers of microvillus membrane integrity revealed that probiotic administration also protected against parasite-induced mucosal damage. In addition, a cellular response to Giardia antigens was stimulated in spleen cells from La1-treated gerbils. Results show for the first time the antigiardial effect of probiotic lactobacilli in vivo and provide further insight into the antagonistic properties of lactic acid bacteria against protozoa involved in intestinal infections.
format Articulo
Articulo
author Humen, Martín Andrés
De Antoni, Graciela Liliana
Benyacoub, Jalil
Costas, María Elena
Cardozo, Marta
Kozubsky, Leonora Eugenia
Saudan, Kim Yen
Boenzli Bruand, Angele
Blum, Stephanie
Schiffrin, Eduardo J.
Pérez, Pablo Fernando
author_facet Humen, Martín Andrés
De Antoni, Graciela Liliana
Benyacoub, Jalil
Costas, María Elena
Cardozo, Marta
Kozubsky, Leonora Eugenia
Saudan, Kim Yen
Boenzli Bruand, Angele
Blum, Stephanie
Schiffrin, Eduardo J.
Pérez, Pablo Fernando
author_sort Humen, Martín Andrés
title Lactobacillus johnsonii La1 antagonizes Giardia intestinalis in vivo
title_short Lactobacillus johnsonii La1 antagonizes Giardia intestinalis in vivo
title_full Lactobacillus johnsonii La1 antagonizes Giardia intestinalis in vivo
title_fullStr Lactobacillus johnsonii La1 antagonizes Giardia intestinalis in vivo
title_full_unstemmed Lactobacillus johnsonii La1 antagonizes Giardia intestinalis in vivo
title_sort lactobacillus johnsonii la1 antagonizes giardia intestinalis in vivo
publishDate 2005
url http://sedici.unlp.edu.ar/handle/10915/83266
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