Development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid

The present study was undertaken to evaluate the effect of glyceryl monostearate (GMS) and stearic acid (SA) on the release profile of gliclazide from the matrix. Matrix tablets for the controlled delivery of gliclazide were prepared by hot melt method using pure and blended mixture of glyceryl mono...

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Detalles Bibliográficos
Autores principales: Hussain, Talib, Saeed, Tariq, Mumtaz, Ahmed M., Jamshaid, Muhammad, Aamir, Muhammad N., Abbas, Khizar, Javaid, Zeshan, Awais, Azeema
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
gliclazide; glyceryl monostearate; matrix tablets; stearic acid; sustained-release
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8326
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_3.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8326
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
gliclazide; glyceryl monostearate; matrix tablets; stearic acid; sustained-release
spellingShingle Farmacia
gliclazide; glyceryl monostearate; matrix tablets; stearic acid; sustained-release
Hussain, Talib
Saeed, Tariq
Mumtaz, Ahmed M.
Jamshaid, Muhammad
Aamir, Muhammad N.
Abbas, Khizar
Javaid, Zeshan
Awais, Azeema
Development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid
topic_facet Farmacia
gliclazide; glyceryl monostearate; matrix tablets; stearic acid; sustained-release
description The present study was undertaken to evaluate the effect of glyceryl monostearate (GMS) and stearic acid (SA) on the release profile of gliclazide from the matrix. Matrix tablets for the controlled delivery of gliclazide were prepared by hot melt method using pure and blended mixture of glyceryl monostearate and stearic acid in different drug to polymer and polymer to polymer ratios. In vitro release characteristics of gliclazide from these hydrophobic matrices were studied over 8 h in phosphate buffer media of pH 7.4. The release kinetics of drug was evaluated for zero order, first order, Higuchi and Peppas kinetic models. It was observed that the release of drug from the matrix was greatly retarded by GMS and retarding effect increased with increasing polymer to drug ratios. On the other hand SA appeared to channel the drug from the wax matrix and release was greatly increased with increasing polymer to drug ratios. The kinetic evaluation of release profile indicated that the Higuchi model was the most appropriate model for describing the release profile of gliclazide. The application of Peppas biexponential equation indicated that non-Fickian release was the predominant mechanism of drug release. The FTIR results showed no interaction between the drug and the polymers and DSC results indicated that both the drug and polymers are in amorphous state and no significant complexes were formed. The results indicated that proper selection of drug to polymer and polymer to polymer ratios were important in order to achieve the desired dissolution profile in these matrix tablets.
format Articulo
Articulo
author Hussain, Talib
Saeed, Tariq
Mumtaz, Ahmed M.
Jamshaid, Muhammad
Aamir, Muhammad N.
Abbas, Khizar
Javaid, Zeshan
Awais, Azeema
author_facet Hussain, Talib
Saeed, Tariq
Mumtaz, Ahmed M.
Jamshaid, Muhammad
Aamir, Muhammad N.
Abbas, Khizar
Javaid, Zeshan
Awais, Azeema
author_sort Hussain, Talib
title Development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid
title_short Development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid
title_full Development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid
title_fullStr Development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid
title_full_unstemmed Development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid
title_sort development of gliclazide matrix tablets from pure and blended mixture of glyceryl monostearate and stearic acid
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8326
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_3.pdf
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