Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy

Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which include whole hearts, are accompanied by an enhanced activity of the Na+/H+ exchanger 1 (NHE-1). Exogenous administration of prohypertrophic agents such as angiotensin II (Ang II), endothelin-1 (ET-1), and...

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Detalles Bibliográficos
Autores principales: Cingolani, Horacio Eugenio, Ennis, Irene Lucía
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2007
Materias:
Ciencias Médicas
Hypertrophy
Signal transduction
Sodium
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83235
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83235
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Hypertrophy
Signal transduction
Sodium
spellingShingle Ciencias Médicas
Hypertrophy
Signal transduction
Sodium
Cingolani, Horacio Eugenio
Ennis, Irene Lucía
Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy
topic_facet Ciencias Médicas
Hypertrophy
Signal transduction
Sodium
description Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which include whole hearts, are accompanied by an enhanced activity of the Na+/H+ exchanger 1 (NHE-1). Exogenous administration of prohypertrophic agents such as angiotensin II (Ang II), endothelin-1 (ET-1), and α1-adrenergic agonists also stimulates NHE-1 activity, which leads to an increased concentration of intracellular Na+ ([Na+]i). Moreover, inhibition of NHE-1 activity prevents the increase in [Na+]i, induces the regression of cardiac hypertrophy, and exerts beneficial effects in experimental heart failure. The present review summarizes the current knowledge of the causative factors and pathophysiological correlation of cardiac overload and NHE-1 activity.
format Articulo
Revision
author Cingolani, Horacio Eugenio
Ennis, Irene Lucía
author_facet Cingolani, Horacio Eugenio
Ennis, Irene Lucía
author_sort Cingolani, Horacio Eugenio
title Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy
title_short Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy
title_full Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy
title_fullStr Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy
title_full_unstemmed Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy
title_sort sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy
publishDate 2007
url http://sedici.unlp.edu.ar/handle/10915/83235
work_keys_str_mv AT cingolanihoracioeugenio sodiumhydrogenexchangercardiacoverloadandmyocardialhypertrophy
AT ennisirenelucia sodiumhydrogenexchangercardiacoverloadandmyocardialhypertrophy
bdutipo_str Repositorios
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