Preparation, crystal structure and prodrug studies of genistein benzensulfonate

4'-ethyl-7-phenylsulfonylgenistein (EPG, 3), a potential prodrug for genistein (1), was synthesized in high yield and its crystal structure was reported firstly. It possesses better physical and chemical properties such as solubility, lipid/water partition coefficient, LogP, and hydrolysis kine...

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Detalles Bibliográficos
Autores principales:	Peng, You, Gan, Li- Jun, Deng, Ze-yuan
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Isoflavonas crystal structure; genistein benzensulfonate; hydrolysis; partition coefficient; prodrug Psicofarmacología Farmacocinética
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8322 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_2_7.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8322
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Isoflavonas crystal structure; genistein benzensulfonate; hydrolysis; partition coefficient; prodrug Psicofarmacología Farmacocinética
spellingShingle	Farmacia Isoflavonas crystal structure; genistein benzensulfonate; hydrolysis; partition coefficient; prodrug Psicofarmacología Farmacocinética Peng, You Gan, Li- Jun Deng, Ze-yuan Preparation, crystal structure and prodrug studies of genistein benzensulfonate
topic_facet	Farmacia Isoflavonas crystal structure; genistein benzensulfonate; hydrolysis; partition coefficient; prodrug Psicofarmacología Farmacocinética
description	4'-ethyl-7-phenylsulfonylgenistein (EPG, 3), a potential prodrug for genistein (1), was synthesized in high yield and its crystal structure was reported firstly. It possesses better physical and chemical properties such as solubility, lipid/water partition coefficient, LogP, and hydrolysis kinetics than its original form. The LogP value (2.07) and the half-life of the hydrolysis value (13.4 h) show that its oral bioavailability is possibly improved evidently compared with that of genistein. These results indicate that EPG can be considered a potential prodrug for genistein.
format	Articulo Comunicacion
author	Peng, You Gan, Li- Jun Deng, Ze-yuan
author_facet	Peng, You Gan, Li- Jun Deng, Ze-yuan
author_sort	Peng, You
title	Preparation, crystal structure and prodrug studies of genistein benzensulfonate
title_short	Preparation, crystal structure and prodrug studies of genistein benzensulfonate
title_full	Preparation, crystal structure and prodrug studies of genistein benzensulfonate
title_fullStr	Preparation, crystal structure and prodrug studies of genistein benzensulfonate
title_full_unstemmed	Preparation, crystal structure and prodrug studies of genistein benzensulfonate
title_sort	preparation, crystal structure and prodrug studies of genistein benzensulfonate
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8322 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_2_7.pdf
work_keys_str_mv	AT pengyou preparationcrystalstructureandprodrugstudiesofgenisteinbenzensulfonate AT ganlijun preparationcrystalstructureandprodrugstudiesofgenisteinbenzensulfonate AT dengzeyuan preparationcrystalstructureandprodrugstudiesofgenisteinbenzensulfonate
bdutipo_str	Repositorios
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Preparation, crystal structure and prodrug studies of genistein benzensulfonate

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