Synthesis and in vitro antimicrobial activity of novel hydrazide-hydrazone derivatives of dodecanoic acid

Six new dodecanoic acid hydrazide-hydrazones (compounds 4a–f), unsubstituted or carrying hydroxy, methoxy, nitro and chloro groups on the benzene ring, were synthesized and tested, in vitro, for their antimicrobial activity against two Gram negative bacteria strains (Escherichia coli and Pseudomonas...

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Autores principales: Kumar, Mahesh, Jain, Sandeep, Deep, Aakash, Phogat, Priyanka
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
antibacterial; antifungal; characterization; long chain aliphatic acid hydrazide; synthesis
Pruebas de Sensibilidad Microbiana
Hidrazonas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8317
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_2_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8317
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
antibacterial; antifungal; characterization; long chain aliphatic acid hydrazide; synthesis
Pruebas de Sensibilidad Microbiana
Hidrazonas
spellingShingle Farmacia
antibacterial; antifungal; characterization; long chain aliphatic acid hydrazide; synthesis
Pruebas de Sensibilidad Microbiana
Hidrazonas
Kumar, Mahesh
Jain, Sandeep
Deep, Aakash
Phogat, Priyanka
Synthesis and in vitro antimicrobial activity of novel hydrazide-hydrazone derivatives of dodecanoic acid
topic_facet Farmacia
antibacterial; antifungal; characterization; long chain aliphatic acid hydrazide; synthesis
Pruebas de Sensibilidad Microbiana
Hidrazonas
description Six new dodecanoic acid hydrazide-hydrazones (compounds 4a–f), unsubstituted or carrying hydroxy, methoxy, nitro and chloro groups on the benzene ring, were synthesized and tested, in vitro, for their antimicrobial activity against two Gram negative bacteria strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive bacteria strains (Bacillus subtilis and Staphylococcus aureus) and two fungal strains (Candida albicans and Aspergillus niger). The microbial screening results indicated that compounds having chloro and nitro substituents were the most active ones. These hydrazone derivatives were characterized by CHN analysis, IR, and 1H NMR spectral data. All newly synthesized compounds exhibited promising results.
format Articulo
Comunicacion
author Kumar, Mahesh
Jain, Sandeep
Deep, Aakash
Phogat, Priyanka
author_facet Kumar, Mahesh
Jain, Sandeep
Deep, Aakash
Phogat, Priyanka
author_sort Kumar, Mahesh
title Synthesis and in vitro antimicrobial activity of novel hydrazide-hydrazone derivatives of dodecanoic acid
title_short Synthesis and in vitro antimicrobial activity of novel hydrazide-hydrazone derivatives of dodecanoic acid
title_full Synthesis and in vitro antimicrobial activity of novel hydrazide-hydrazone derivatives of dodecanoic acid
title_fullStr Synthesis and in vitro antimicrobial activity of novel hydrazide-hydrazone derivatives of dodecanoic acid
title_full_unstemmed Synthesis and in vitro antimicrobial activity of novel hydrazide-hydrazone derivatives of dodecanoic acid
title_sort synthesis and in vitro antimicrobial activity of novel hydrazide-hydrazone derivatives of dodecanoic acid
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8317
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_2_2.pdf
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AT deepaakash synthesisandinvitroantimicrobialactivityofnovelhydrazidehydrazonederivativesofdodecanoicacid
AT phogatpriyanka synthesisandinvitroantimicrobialactivityofnovelhydrazidehydrazonederivativesofdodecanoicacid
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