Inhibition of fluconazole in vitro antifungal activity in formulations containing propylene glycol

Inhibition action of propylene glycol (PG) on the antifungal activity of fluconazole has been investigated. PG was used as cosolvent and penetration enhancer in different solutions and topical dosage forms. The interaction was analyzed by comparing with Transcutol P® (TCL), another cosolvent and pen...

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Autores principales:	Salerno, Claudia, Carlucci, Adriana M., Chiappetta, Diego A., Bregni, Carlos
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia antifungal activity; fluconazole; hydrogen bonding; propylene glycol Triazoles Glicoles Agentes Antifúngicos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8314 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_25.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8314
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia antifungal activity; fluconazole; hydrogen bonding; propylene glycol Triazoles Glicoles Agentes Antifúngicos
spellingShingle	Farmacia antifungal activity; fluconazole; hydrogen bonding; propylene glycol Triazoles Glicoles Agentes Antifúngicos Salerno, Claudia Carlucci, Adriana M. Chiappetta, Diego A. Bregni, Carlos Inhibition of fluconazole in vitro antifungal activity in formulations containing propylene glycol
topic_facet	Farmacia antifungal activity; fluconazole; hydrogen bonding; propylene glycol Triazoles Glicoles Agentes Antifúngicos
description	Inhibition action of propylene glycol (PG) on the antifungal activity of fluconazole has been investigated. PG was used as cosolvent and penetration enhancer in different solutions and topical dosage forms. The interaction was analyzed by comparing with Transcutol P® (TCL), another cosolvent and penetration enhancer. Solubility of the drug was evaluated in aqueous solutions containing PG or TCL and the crystallized drug was studied by both DSC and FTIR. Solutions of the drug in the solvents were studied by FTIR and UV spectroscopy. Antifungal activity was determined for solutions with several concentrations of PG/TCL and in dosage forms with PG 10 %. Candida albicans was used as a model fungus and a procedure with standardized inoculum concentration was used. Results showed lower antifungal activity of fluconazole solutions and topical dosage forms when propylene glycol is included. Although crystallization is faster in PG solutions, solubility proved not to be the cause, but changes in FTIR spectra suggested that different hydrogen bond formation could explain the decrease in activity.
format	Articulo Articulo
author	Salerno, Claudia Carlucci, Adriana M. Chiappetta, Diego A. Bregni, Carlos
author_facet	Salerno, Claudia Carlucci, Adriana M. Chiappetta, Diego A. Bregni, Carlos
author_sort	Salerno, Claudia
title	Inhibition of fluconazole in vitro antifungal activity in formulations containing propylene glycol
title_short	Inhibition of fluconazole in vitro antifungal activity in formulations containing propylene glycol
title_full	Inhibition of fluconazole in vitro antifungal activity in formulations containing propylene glycol
title_fullStr	Inhibition of fluconazole in vitro antifungal activity in formulations containing propylene glycol
title_full_unstemmed	Inhibition of fluconazole in vitro antifungal activity in formulations containing propylene glycol
title_sort	inhibition of fluconazole in vitro antifungal activity in formulations containing propylene glycol
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8314 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_25.pdf
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bdutipo_str	Repositorios
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Inhibition of fluconazole in vitro antifungal activity in formulations containing propylene glycol

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