Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies

Bordetella pertussis attachment to host cells is a crucial step in colonization. In this study, we investigated the specificity of antibodies, induced either by vaccination or infection, capable of reducing bacterial adherence to respiratory epithelial cells. Both sera and purified anti-B. pertussis...

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Detalles Bibliográficos
Autores principales: Rodríguez, María Eugenia, Hellwig, Sandra M.M., Pérez Vidakovics, María Laura Anabella, Berbers, Guy A.M., Van De Winkel, Jan G.J.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2006
Materias:
Biología
Antibody
Bordetella pertussis
Fimbriae
Host protection
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83112
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83112
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Antibody
Bordetella pertussis
Fimbriae
Host protection
spellingShingle Biología
Antibody
Bordetella pertussis
Fimbriae
Host protection
Rodríguez, María Eugenia
Hellwig, Sandra M.M.
Pérez Vidakovics, María Laura Anabella
Berbers, Guy A.M.
Van De Winkel, Jan G.J.
Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies
topic_facet Biología
Antibody
Bordetella pertussis
Fimbriae
Host protection
description Bordetella pertussis attachment to host cells is a crucial step in colonization. In this study, we investigated the specificity of antibodies, induced either by vaccination or infection, capable of reducing bacterial adherence to respiratory epithelial cells. Both sera and purified anti-B. pertussis IgG or IgA fractions efficiently reduced attachment. This effect was found to be mediated mainly by fimbriae-specific antibodies. Antibodies with other specificities did not significantly interfere in the interaction of B. pertussis with respiratory epithelial cells, with the exception of antifilamentous hemaglutinin antibodies, which reduced bacterial attachment. However, this effect was smaller in magnitude than that observed in the presence of fimbriae-specific antibodies. The strong agglutinating activity of antifimbriae antibodies seems to be involved in this phenomenon.
format Articulo
Articulo
author Rodríguez, María Eugenia
Hellwig, Sandra M.M.
Pérez Vidakovics, María Laura Anabella
Berbers, Guy A.M.
Van De Winkel, Jan G.J.
author_facet Rodríguez, María Eugenia
Hellwig, Sandra M.M.
Pérez Vidakovics, María Laura Anabella
Berbers, Guy A.M.
Van De Winkel, Jan G.J.
author_sort Rodríguez, María Eugenia
title Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies
title_short Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies
title_full Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies
title_fullStr Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies
title_full_unstemmed Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies
title_sort bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies
publishDate 2006
url http://sedici.unlp.edu.ar/handle/10915/83112
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