Development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using DD-Solver

The aim of this study was to develop sustained release formulation for improving bioavailability of metronidazole designing metronidazole loaded chitosan microcapsules (MLCM) using coacervation technique. Two solutions with different pH nature i.e. chitosan solution in 5 % glacial acetic acid contai...

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Autor principal: Murtaza, Ghulam
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
characterization; chitosan; coacervation; glutaraldehyde; metronidazole
Quitina
Nitroimidazoles
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8311
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_22.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8311
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
characterization; chitosan; coacervation; glutaraldehyde; metronidazole
Quitina
Nitroimidazoles
spellingShingle Farmacia
characterization; chitosan; coacervation; glutaraldehyde; metronidazole
Quitina
Nitroimidazoles
Murtaza, Ghulam
Development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using DD-Solver
topic_facet Farmacia
characterization; chitosan; coacervation; glutaraldehyde; metronidazole
Quitina
Nitroimidazoles
description The aim of this study was to develop sustained release formulation for improving bioavailability of metronidazole designing metronidazole loaded chitosan microcapsules (MLCM) using coacervation technique. Two solutions with different pH nature i.e. chitosan solution in 5 % glacial acetic acid containing metronidazole and 2 M NaOH solution were employed for the induction of coacervation. Glutaraldehyde was used as cross-linking agent. Different MLCM formulations were fabricated by varying chitosan and glutaraldehyde concentrations. Dissolution data was evaluated using new software, DDSolver. Microcapsules were discrete, brown, spherical and porous. Microcapsule size range was 343.6 ± 8.9 μm – 401.9 ± 9.6 μm and the entrapment efficiency ranged from 45.2 ± 6.4 – 64.3 ± 5.7 for all formulations. The F6 formulation with drug/polymer ratio 1:2 (w/w) was optimum regarding entrapment efficiency (64.3 ± 5.7 %), flow characteristics (Hausner’s ratio = 1.3-1.5) and drug release properties, in all cases. The kinetic analysis of dissolution data confirmed diffusion controlled release of metronidazole from its microcapsules. From the results, it can be concluded that metronidazole can be successfully microencapsulated into the chitosan shells by coacervation and is influenced significantly by the quantity of chitosan and glutaraldehyde employed.
format Articulo
Articulo
author Murtaza, Ghulam
author_facet Murtaza, Ghulam
author_sort Murtaza, Ghulam
title Development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using DD-Solver
title_short Development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using DD-Solver
title_full Development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using DD-Solver
title_fullStr Development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using DD-Solver
title_full_unstemmed Development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using DD-Solver
title_sort development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using dd-solver
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8311
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_22.pdf
work_keys_str_mv AT murtazaghulam developmentofglutaraldehydecrosslinkedmetronidazoleloadedchitosanmicrocapsulesanalysisofdissolutiondatausingddsolver
bdutipo_str Repositorios
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