Preparation and characterization of spherical agglomerates of piroxicam

The purpose of the present study was to prepare spherical agglomerates (SA) of piroxicam by solvent change method. Crystallization medium used for spherical agglomerates of piroxicam consisted of DMF:water and chloroform. The presence of solvents residual in SA was determined by gas chromatography a...

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Autores principales: Dixit, Mudit, Kulkarni, Parthasarathi K.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
crystallinity; dissolution; piroxicam; spherical agglomerates; stability study
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8310
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_21.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8310
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
crystallinity; dissolution; piroxicam; spherical agglomerates; stability study
spellingShingle Farmacia
crystallinity; dissolution; piroxicam; spherical agglomerates; stability study
Dixit, Mudit
Kulkarni, Parthasarathi K.
Preparation and characterization of spherical agglomerates of piroxicam
topic_facet Farmacia
crystallinity; dissolution; piroxicam; spherical agglomerates; stability study
description The purpose of the present study was to prepare spherical agglomerates (SA) of piroxicam by solvent change method. Crystallization medium used for spherical agglomerates of piroxicam consisted of DMF:water and chloroform. The presence of solvents residual in SA was determined by gas chromatography and were particles were characterized by DSC, FT-IR, XRD and SEM. The respective solubility study and dissolution behavior studies were carried out. The samples were stored in stability chamber to investigate their physical stabilities. Solvents residuals in SA were found to be within the limits and exhibited decreased crystallinity of piroxicam in SA than pure piroxicam. The solubility and dissolution of the spherical agglomerates was improved compared with pure piroxicam and recrystallized sample. In stability test, the release profile of the spherical agglomeration was almost unchanged as compared with the freshly prepared spherical agglomeration stored at 20 °C and 45 % relative humidity for 90 days. Hence this technique can be used to obtain modified drug raw material for formulation of tablets of piroxicam by direct compression with directly compressible tablet excipients.
format Articulo
Articulo
author Dixit, Mudit
Kulkarni, Parthasarathi K.
author_facet Dixit, Mudit
Kulkarni, Parthasarathi K.
author_sort Dixit, Mudit
title Preparation and characterization of spherical agglomerates of piroxicam
title_short Preparation and characterization of spherical agglomerates of piroxicam
title_full Preparation and characterization of spherical agglomerates of piroxicam
title_fullStr Preparation and characterization of spherical agglomerates of piroxicam
title_full_unstemmed Preparation and characterization of spherical agglomerates of piroxicam
title_sort preparation and characterization of spherical agglomerates of piroxicam
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8310
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_21.pdf
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AT kulkarniparthasarathik preparationandcharacterizationofsphericalagglomeratesofpiroxicam
bdutipo_str Repositorios
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