Determination of diphenhydramine hydrochloride in rabbit plasma by LC-MS/MS and its application to a pharmacokinetic study

A sensitive and selective liquid chromatography tandem mass spectrometry (LC-MS/MS) method for determination of diphenhydramine hydrochloride in rabbit plasma was developed and validated. After addition of triazolam as internal standard (IS), protein precipitation by acetonitrile was used as sample...

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Detalles Bibliográficos
Autores principales:	Ma Jianshe, Zhang, Meiling, Shentu, Yangping, Zhang, Yuqing, Fan, Xiaofang, Gong, Yongsheng
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia diphenhydramine hydrochloride; liquid chromatography-tandem mass spectrometry; pharmacokinetics; plasm Etilaminas Técnicas de Química Analítica Sangre
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8308 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_19.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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