Synthesis and biological activities of novel danshensu amide derivatives as anti-myocardial ischemia agents

A series of novel danshensu amide derivatives were synthesized, and the protective effects of all the compounds on rat myocardial cell lines H9C2 by hypoxia were investigated. The results showed that all the seven compounds could significantly increased cell viability compared with hypoxia group. Am...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang, Tingfang, Shu, Jingjing, Zheng, Liping, Xiong, Liyan, Wang, Jing, Jin, Lei, Wu, Qiuye, Zou, Hao, Zhang, Chuan
Formato:	Articulo
Lenguaje:	Español
Publicado:	2011
Materias:	Farmacia anti-myocardial ischemia activities; danshensu amide derivatives; lipophilicity; synthesis
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8305 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_16.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8305
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Español
topic	Farmacia anti-myocardial ischemia activities; danshensu amide derivatives; lipophilicity; synthesis
spellingShingle	Farmacia anti-myocardial ischemia activities; danshensu amide derivatives; lipophilicity; synthesis Wang, Tingfang Shu, Jingjing Zheng, Liping Xiong, Liyan Wang, Jing Jin, Lei Wu, Qiuye Zou, Hao Zhang, Chuan Synthesis and biological activities of novel danshensu amide derivatives as anti-myocardial ischemia agents
topic_facet	Farmacia anti-myocardial ischemia activities; danshensu amide derivatives; lipophilicity; synthesis
description	A series of novel danshensu amide derivatives were synthesized, and the protective effects of all the compounds on rat myocardial cell lines H9C2 by hypoxia were investigated. The results showed that all the seven compounds could significantly increased cell viability compared with hypoxia group. Among these compounds, 3-(3,4-dimethoxyphenyl)-2-hydroxy-N-propylpropanamide (6) exhibited good activities, with cell viability reached 94.2 % compared to the normal. The novel danshensu amide derivatives, possessing an additional lipophilic alkyl chain showed a good lipophilicity.
format	Articulo Articulo
author	Wang, Tingfang Shu, Jingjing Zheng, Liping Xiong, Liyan Wang, Jing Jin, Lei Wu, Qiuye Zou, Hao Zhang, Chuan
author_facet	Wang, Tingfang Shu, Jingjing Zheng, Liping Xiong, Liyan Wang, Jing Jin, Lei Wu, Qiuye Zou, Hao Zhang, Chuan
author_sort	Wang, Tingfang
title	Synthesis and biological activities of novel danshensu amide derivatives as anti-myocardial ischemia agents
title_short	Synthesis and biological activities of novel danshensu amide derivatives as anti-myocardial ischemia agents
title_full	Synthesis and biological activities of novel danshensu amide derivatives as anti-myocardial ischemia agents
title_fullStr	Synthesis and biological activities of novel danshensu amide derivatives as anti-myocardial ischemia agents
title_full_unstemmed	Synthesis and biological activities of novel danshensu amide derivatives as anti-myocardial ischemia agents
title_sort	synthesis and biological activities of novel danshensu amide derivatives as anti-myocardial ischemia agents
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8305 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_16.pdf
work_keys_str_mv	AT wangtingfang synthesisandbiologicalactivitiesofnoveldanshensuamidederivativesasantimyocardialischemiaagents AT shujingjing synthesisandbiologicalactivitiesofnoveldanshensuamidederivativesasantimyocardialischemiaagents AT zhengliping synthesisandbiologicalactivitiesofnoveldanshensuamidederivativesasantimyocardialischemiaagents AT xiongliyan synthesisandbiologicalactivitiesofnoveldanshensuamidederivativesasantimyocardialischemiaagents AT wangjing synthesisandbiologicalactivitiesofnoveldanshensuamidederivativesasantimyocardialischemiaagents AT jinlei synthesisandbiologicalactivitiesofnoveldanshensuamidederivativesasantimyocardialischemiaagents AT wuqiuye synthesisandbiologicalactivitiesofnoveldanshensuamidederivativesasantimyocardialischemiaagents AT zouhao synthesisandbiologicalactivitiesofnoveldanshensuamidederivativesasantimyocardialischemiaagents AT zhangchuan synthesisandbiologicalactivitiesofnoveldanshensuamidederivativesasantimyocardialischemiaagents
bdutipo_str	Repositorios
_version_	1764820488232632324

Synthesis and biological activities of novel danshensu amide derivatives as anti-myocardial ischemia agents

Ejemplares similares