In vitro spermatostatic activity of mulinane- and azorellane-type diterpenes on human spermatozoa

Mulinenic acid (1), mulinolic acid (2) and azorellan- 17,13- (β) olide (3) isolated from Mulinum spinosum and Azorella trifurcata have been evaluated for their spermatostatic activity on human spermatozoa. In vitro sperm motility, viability and recovery of the motility were assessed. Compounds 2 and...

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Autores principales: Chiaramello, Alejandra I., Yunes, Roberto, Rossomando, Pedro, Cifuente, Diego A.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
azorellan-17,13-(β)olide; mulinenic acid; mulinolic acid; spermatostatic bioactivity; sperm viability; sperm motility
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8301
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_11.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8301
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
azorellan-17,13-(β)olide; mulinenic acid; mulinolic acid; spermatostatic bioactivity; sperm viability; sperm motility
spellingShingle Farmacia
azorellan-17,13-(β)olide; mulinenic acid; mulinolic acid; spermatostatic bioactivity; sperm viability; sperm motility
Chiaramello, Alejandra I.
Yunes, Roberto
Rossomando, Pedro
Cifuente, Diego A.
In vitro spermatostatic activity of mulinane- and azorellane-type diterpenes on human spermatozoa
topic_facet Farmacia
azorellan-17,13-(β)olide; mulinenic acid; mulinolic acid; spermatostatic bioactivity; sperm viability; sperm motility
description Mulinenic acid (1), mulinolic acid (2) and azorellan- 17,13- (β) olide (3) isolated from Mulinum spinosum and Azorella trifurcata have been evaluated for their spermatostatic activity on human spermatozoa. In vitro sperm motility, viability and recovery of the motility were assessed. Compounds 2 and 3 showed significant spermatostatic properties. Reversible effects for 2 (% Motile Cells = 32 ± 3, % Living Cells = 84 ± 4) and irreversible effects for 3 (% Motile Cells = 34 ± 4, % Living Cells = 82 ± 4) were observed. Compound 1 showed moderate bioactivity. Compounds 2-3 presented remarkable effects on human sperm motility and we were encouraged to consider their application as a potential non hormonal male contraceptive agent.
format Articulo
Articulo
author Chiaramello, Alejandra I.
Yunes, Roberto
Rossomando, Pedro
Cifuente, Diego A.
author_facet Chiaramello, Alejandra I.
Yunes, Roberto
Rossomando, Pedro
Cifuente, Diego A.
author_sort Chiaramello, Alejandra I.
title In vitro spermatostatic activity of mulinane- and azorellane-type diterpenes on human spermatozoa
title_short In vitro spermatostatic activity of mulinane- and azorellane-type diterpenes on human spermatozoa
title_full In vitro spermatostatic activity of mulinane- and azorellane-type diterpenes on human spermatozoa
title_fullStr In vitro spermatostatic activity of mulinane- and azorellane-type diterpenes on human spermatozoa
title_full_unstemmed In vitro spermatostatic activity of mulinane- and azorellane-type diterpenes on human spermatozoa
title_sort in vitro spermatostatic activity of mulinane- and azorellane-type diterpenes on human spermatozoa
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8301
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_11.pdf
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