Stereospecific dissolution of inclusion complexes of amlodipine base and its besylate enantiomers with hydroxypropyl-β-cyclodextrin

The objective of this work was the preparation of inclusion complexes of amlodipine base and its besylate salt with hydroxy propyl-β-cyclodextrin (HPBC) to improve the dissolution and to investigate the stereospecific dissolution of amlodipine enantiomers. The prepared inclusion complexes were chara...

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Detalles Bibliográficos
Autores principales: Somagoni, Jagan M., Dharani, Sathis, Panakanti, Pavan K., Koorelli, Someshwar, Manda, Sarangapani, Rao, Yamsani Madhusudan
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Dihidropiridinas
amlodipine enantiomers; hydroxy propyl-β-cyclodextrin; inclusion complex; stereospecificity
Disolución
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8299
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_9.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8299
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Dihidropiridinas
amlodipine enantiomers; hydroxy propyl-β-cyclodextrin; inclusion complex; stereospecificity
Disolución
spellingShingle Farmacia
Dihidropiridinas
amlodipine enantiomers; hydroxy propyl-β-cyclodextrin; inclusion complex; stereospecificity
Disolución
Somagoni, Jagan M.
Dharani, Sathis
Panakanti, Pavan K.
Koorelli, Someshwar
Manda, Sarangapani
Rao, Yamsani Madhusudan
Stereospecific dissolution of inclusion complexes of amlodipine base and its besylate enantiomers with hydroxypropyl-β-cyclodextrin
topic_facet Farmacia
Dihidropiridinas
amlodipine enantiomers; hydroxy propyl-β-cyclodextrin; inclusion complex; stereospecificity
Disolución
description The objective of this work was the preparation of inclusion complexes of amlodipine base and its besylate salt with hydroxy propyl-β-cyclodextrin (HPBC) to improve the dissolution and to investigate the stereospecific dissolution of amlodipine enantiomers. The prepared inclusion complexes were characterized by FTIR and DSC. Significant improvement in the dissolution was found with S and R enantiomers of amlodipine base where as no improvement was found with enantiomers of amlodipine besylate (p > 0.05) after complexation with HPBC. This indicates the formation of inclusion complexes with only enantiomers of amlodipine base (p < 0.05). No stereospecific dissolution was found with pure amlodipine besylate enantiomers. In case of physical mixing no inclusion complexes were formed even with enantiomers of amlodipine base (p > 0.05). Stereospecific dissolution was observed with pure enantiomers of amlodipine base when its inclusion complexes were prepared by solvent evaporation method with l:1 and 1:2 molar ratios but not with 1:3 molar ratio.
format Articulo
Articulo
author Somagoni, Jagan M.
Dharani, Sathis
Panakanti, Pavan K.
Koorelli, Someshwar
Manda, Sarangapani
Rao, Yamsani Madhusudan
author_facet Somagoni, Jagan M.
Dharani, Sathis
Panakanti, Pavan K.
Koorelli, Someshwar
Manda, Sarangapani
Rao, Yamsani Madhusudan
author_sort Somagoni, Jagan M.
title Stereospecific dissolution of inclusion complexes of amlodipine base and its besylate enantiomers with hydroxypropyl-β-cyclodextrin
title_short Stereospecific dissolution of inclusion complexes of amlodipine base and its besylate enantiomers with hydroxypropyl-β-cyclodextrin
title_full Stereospecific dissolution of inclusion complexes of amlodipine base and its besylate enantiomers with hydroxypropyl-β-cyclodextrin
title_fullStr Stereospecific dissolution of inclusion complexes of amlodipine base and its besylate enantiomers with hydroxypropyl-β-cyclodextrin
title_full_unstemmed Stereospecific dissolution of inclusion complexes of amlodipine base and its besylate enantiomers with hydroxypropyl-β-cyclodextrin
title_sort stereospecific dissolution of inclusion complexes of amlodipine base and its besylate enantiomers with hydroxypropyl-β-cyclodextrin
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8299
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_9.pdf
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AT panakantipavank stereospecificdissolutionofinclusioncomplexesofamlodipinebaseanditsbesylateenantiomerswithhydroxypropylbcyclodextrin
AT koorellisomeshwar stereospecificdissolutionofinclusioncomplexesofamlodipinebaseanditsbesylateenantiomerswithhydroxypropylbcyclodextrin
AT mandasarangapani stereospecificdissolutionofinclusioncomplexesofamlodipinebaseanditsbesylateenantiomerswithhydroxypropylbcyclodextrin
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