Antinociceptive activity of acetylbergenin in mice
Endopleura uchi (Huber) Cuatrec. (Humiriaceae), a Brazilian Amazon plant, is used in folk medicine for the treatment of arthritis. Bergenin, one of the chemical constituents of E. uchi, has several biological activities, including anti-inflammatory properties. Acetylbergenin was obtained from acetyl...
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8298 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_8.pdf |
| Aporte de: |
| id |
I19-R120-10915-8298 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia acetylbergenin; antinociceptive activity; bergenin; endopleura uchi Plantas Medicinales Analgésicos Compuestos Fenólicos |
| spellingShingle |
Farmacia acetylbergenin; antinociceptive activity; bergenin; endopleura uchi Plantas Medicinales Analgésicos Compuestos Fenólicos Borges, Jaqueline C. M. Ripardo Filho, Haroldo da S. Guilhon, Giselle M.S.P. Carvalho, José C. T. Santos, Lourivaldo S. Sousa, Pergentino J.C. Antinociceptive activity of acetylbergenin in mice |
| topic_facet |
Farmacia acetylbergenin; antinociceptive activity; bergenin; endopleura uchi Plantas Medicinales Analgésicos Compuestos Fenólicos |
| description |
Endopleura uchi (Huber) Cuatrec. (Humiriaceae), a Brazilian Amazon plant, is used in folk medicine for the treatment of arthritis. Bergenin, one of the chemical constituents of E. uchi, has several biological activities, including anti-inflammatory properties. Acetylbergenin was obtained from acetylation of bergenin to investigate the antinociceptive effect assessed in models of nociception in mice. This compound dosed at 1, 5, 10, 15 and 25 mg/kg in the writhing test reduced the abdominal constrictions in a significant manner, in 28.2 %, 52.7 %, 61.1 %, 68.3 % and 95.0 %, respectively with ED50 of 6.8 mg/kg. Acetylbergenin in the hot plate test was assayed at 6.8 mg/kg producing no alterations in the latency time when compared to the control. It was tested at 6.8 mg/kg in the formalin test inhibiting significantly the second phase of the algic stimulous, in 88.3 %. These results suggest that acetylbergenin has analgesic activity, probably of peripheral origin. The mechanism involved is not completely understood, however, the results suggest that the opioid system must be involved in the antinociceptive action. |
| format |
Articulo Articulo |
| author |
Borges, Jaqueline C. M. Ripardo Filho, Haroldo da S. Guilhon, Giselle M.S.P. Carvalho, José C. T. Santos, Lourivaldo S. Sousa, Pergentino J.C. |
| author_facet |
Borges, Jaqueline C. M. Ripardo Filho, Haroldo da S. Guilhon, Giselle M.S.P. Carvalho, José C. T. Santos, Lourivaldo S. Sousa, Pergentino J.C. |
| author_sort |
Borges, Jaqueline C. M. |
| title |
Antinociceptive activity of acetylbergenin in mice |
| title_short |
Antinociceptive activity of acetylbergenin in mice |
| title_full |
Antinociceptive activity of acetylbergenin in mice |
| title_fullStr |
Antinociceptive activity of acetylbergenin in mice |
| title_full_unstemmed |
Antinociceptive activity of acetylbergenin in mice |
| title_sort |
antinociceptive activity of acetylbergenin in mice |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8298 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_8.pdf |
| work_keys_str_mv |
AT borgesjaquelinecm antinociceptiveactivityofacetylbergenininmice AT ripardofilhoharoldodas antinociceptiveactivityofacetylbergenininmice AT guilhongisellemsp antinociceptiveactivityofacetylbergenininmice AT carvalhojosect antinociceptiveactivityofacetylbergenininmice AT santoslourivaldos antinociceptiveactivityofacetylbergenininmice AT sousapergentinojc antinociceptiveactivityofacetylbergenininmice |
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Repositorios |
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1764820488127774724 |