Improved delivery of repaglinide through different polymeric devices

Repaglinide (RGL) loaded polymeric drug delivery devices like microcapsules (MC) and transdermal patches (TDP) were formulated and there in vitro-in vivo parameters compared to find out the best route of drug delivery. The formulations were subjected to various studies like hypoglycemic activity, gl...

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Detalles Bibliográficos
Autores principales: Mishra, Manoj K., Sharma, Rishikesh, Ray, Debajyoti
Formato: Articulo
Lenguaje:Español
Publicado: 2011
Materias:
Farmacia
microcapsules; transdermal patch; repaglinide; pharmacokinetics
Vías de Administración de Medicamentos
Agentes Hipoglucémicos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8296
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_6.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8296
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Farmacia
microcapsules; transdermal patch; repaglinide; pharmacokinetics
Vías de Administración de Medicamentos
Agentes Hipoglucémicos
spellingShingle Farmacia
microcapsules; transdermal patch; repaglinide; pharmacokinetics
Vías de Administración de Medicamentos
Agentes Hipoglucémicos
Mishra, Manoj K.
Sharma, Rishikesh
Ray, Debajyoti
Improved delivery of repaglinide through different polymeric devices
topic_facet Farmacia
microcapsules; transdermal patch; repaglinide; pharmacokinetics
Vías de Administración de Medicamentos
Agentes Hipoglucémicos
description Repaglinide (RGL) loaded polymeric drug delivery devices like microcapsules (MC) and transdermal patches (TDP) were formulated and there in vitro-in vivo parameters compared to find out the best route of drug delivery. The formulations were subjected to various studies like hypoglycemic activity, glucose tolerance and pharmacokinetic studies. The formulation TDP1 having drug-polymer ratio 1:1 showed comparatively higher RGL release and better permeation across mice skin. Comparatively higher RGL content was found in TDP1 (99.6 ± 1.8 %) than MC1 (89.2 ± 2.3 %). From the glucose tolerance test, transdermal route effectively maintained the normoglycemic levels in contrast to the oral group, which produced remarkable hypoglycemia. The significantly high area under curve (AUC) values observed with transdermal system also indicate increased bioavailability of drug from these systems compared to oral route. The transdermal system of RGL exhibited better control of hyperglycemia besides more effectively reversing the complications associated with diabetes mellitus than oral administration in mice.
format Articulo
Articulo
author Mishra, Manoj K.
Sharma, Rishikesh
Ray, Debajyoti
author_facet Mishra, Manoj K.
Sharma, Rishikesh
Ray, Debajyoti
author_sort Mishra, Manoj K.
title Improved delivery of repaglinide through different polymeric devices
title_short Improved delivery of repaglinide through different polymeric devices
title_full Improved delivery of repaglinide through different polymeric devices
title_fullStr Improved delivery of repaglinide through different polymeric devices
title_full_unstemmed Improved delivery of repaglinide through different polymeric devices
title_sort improved delivery of repaglinide through different polymeric devices
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8296
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_6.pdf
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AT sharmarishikesh improveddeliveryofrepaglinidethroughdifferentpolymericdevices
AT raydebajyoti improveddeliveryofrepaglinidethroughdifferentpolymericdevices
bdutipo_str Repositorios
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