Design, synthesis and antimicrobial activity of 4-thiazolidinonyl-quinazolin-4(3H)-ones of diclofenac analogue

A series of 7-chloro-3-(2-substituted phenyl-4-oxo-thiazolidin-3-yl)-2-[2-(2,6-dichlorophenyl) amino]benzyl-quinazolin-4(3H)-ones (5a-j) have been synthesized and characterized by elemental analyses as well as IR and NMR spectra. The Schiff bases 4a-j and 4-thiazolidinones 5a-j have been sceened for...

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Detalles Bibliográficos
Autores principales: Patel, Jaymin C., Patel, Virendra N., Patel, Navin B.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
antimicrobial activity; diclofenac; quinazolin-4(3H)-one; 4-thiazolidinone
Quinazolinas
Fenilacetatos
Productos con Acción Antimicrobiana
Técnicas de Química Analítica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8294
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:A series of 7-chloro-3-(2-substituted phenyl-4-oxo-thiazolidin-3-yl)-2-[2-(2,6-dichlorophenyl) amino]benzyl-quinazolin-4(3H)-ones (5a-j) have been synthesized and characterized by elemental analyses as well as IR and NMR spectra. The Schiff bases 4a-j and 4-thiazolidinones 5a-j have been sceened for in vitro antimicrobial activity by cup-plate method. Compounds 4f, 4g, 4h, 5f, 5g and 5h possessed very good antibacterial as well as antifungal activity.

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