Design, synthesis and antimicrobial activity of 4-thiazolidinonyl-quinazolin-4(3H)-ones of diclofenac analogue

A series of 7-chloro-3-(2-substituted phenyl-4-oxo-thiazolidin-3-yl)-2-[2-(2,6-dichlorophenyl) amino]benzyl-quinazolin-4(3H)-ones (5a-j) have been synthesized and characterized by elemental analyses as well as IR and NMR spectra. The Schiff bases 4a-j and 4-thiazolidinones 5a-j have been sceened for...

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Autores principales: Patel, Jaymin C., Patel, Virendra N., Patel, Navin B.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
antimicrobial activity; diclofenac; quinazolin-4(3H)-one; 4-thiazolidinone
Quinazolinas
Fenilacetatos
Productos con Acción Antimicrobiana
Técnicas de Química Analítica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8294
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8294
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
antimicrobial activity; diclofenac; quinazolin-4(3H)-one; 4-thiazolidinone
Quinazolinas
Fenilacetatos
Productos con Acción Antimicrobiana
Técnicas de Química Analítica
spellingShingle Farmacia
antimicrobial activity; diclofenac; quinazolin-4(3H)-one; 4-thiazolidinone
Quinazolinas
Fenilacetatos
Productos con Acción Antimicrobiana
Técnicas de Química Analítica
Patel, Jaymin C.
Patel, Virendra N.
Patel, Navin B.
Design, synthesis and antimicrobial activity of 4-thiazolidinonyl-quinazolin-4(3H)-ones of diclofenac analogue
topic_facet Farmacia
antimicrobial activity; diclofenac; quinazolin-4(3H)-one; 4-thiazolidinone
Quinazolinas
Fenilacetatos
Productos con Acción Antimicrobiana
Técnicas de Química Analítica
description A series of 7-chloro-3-(2-substituted phenyl-4-oxo-thiazolidin-3-yl)-2-[2-(2,6-dichlorophenyl) amino]benzyl-quinazolin-4(3H)-ones (5a-j) have been synthesized and characterized by elemental analyses as well as IR and NMR spectra. The Schiff bases 4a-j and 4-thiazolidinones 5a-j have been sceened for in vitro antimicrobial activity by cup-plate method. Compounds 4f, 4g, 4h, 5f, 5g and 5h possessed very good antibacterial as well as antifungal activity.
format Articulo
Articulo
author Patel, Jaymin C.
Patel, Virendra N.
Patel, Navin B.
author_facet Patel, Jaymin C.
Patel, Virendra N.
Patel, Navin B.
author_sort Patel, Jaymin C.
title Design, synthesis and antimicrobial activity of 4-thiazolidinonyl-quinazolin-4(3H)-ones of diclofenac analogue
title_short Design, synthesis and antimicrobial activity of 4-thiazolidinonyl-quinazolin-4(3H)-ones of diclofenac analogue
title_full Design, synthesis and antimicrobial activity of 4-thiazolidinonyl-quinazolin-4(3H)-ones of diclofenac analogue
title_fullStr Design, synthesis and antimicrobial activity of 4-thiazolidinonyl-quinazolin-4(3H)-ones of diclofenac analogue
title_full_unstemmed Design, synthesis and antimicrobial activity of 4-thiazolidinonyl-quinazolin-4(3H)-ones of diclofenac analogue
title_sort design, synthesis and antimicrobial activity of 4-thiazolidinonyl-quinazolin-4(3h)-ones of diclofenac analogue
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8294
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_4.pdf
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AT patelnavinb designsynthesisandantimicrobialactivityof4thiazolidinonylquinazolin43honesofdiclofenacanalogue
bdutipo_str Repositorios
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