Synthesis, antibacterial activities and molecular docking studies of ethyl 3-(4-substituted phenyl) propanoates as targeted antibiotics

Type II fatty acid synthesis (FAS II) pathway has been recently reported as an attractive targeting for their efficacy against infections caused by multi-resistant Gram-positive and Gram-negative bacteria. Among the related FAS II enzymes, beta ketoacyl-acyl carrier protein synthase (KAS), is an ess...

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Detalles Bibliográficos
Autores principales: Vasanthakumari, Pradeepchandran R., Narasimha, Jayaveera K., Rajarathnam, Vijaianand, Palani, Kumarnallasivan, Ramasamy, Venkatnarayanan, Ramaraj, Sivakumar, Panneerselvam, Arulraj
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Propionatos
cinnamic esters; antibacterial activity; autodock; ecKAS III
Agentes Antibacterianos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8293
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_3.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8293
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Propionatos
cinnamic esters; antibacterial activity; autodock; ecKAS III
Agentes Antibacterianos
spellingShingle Farmacia
Propionatos
cinnamic esters; antibacterial activity; autodock; ecKAS III
Agentes Antibacterianos
Vasanthakumari, Pradeepchandran R.
Narasimha, Jayaveera K.
Rajarathnam, Vijaianand
Palani, Kumarnallasivan
Ramasamy, Venkatnarayanan
Ramaraj, Sivakumar
Panneerselvam, Arulraj
Synthesis, antibacterial activities and molecular docking studies of ethyl 3-(4-substituted phenyl) propanoates as targeted antibiotics
topic_facet Farmacia
Propionatos
cinnamic esters; antibacterial activity; autodock; ecKAS III
Agentes Antibacterianos
description Type II fatty acid synthesis (FAS II) pathway has been recently reported as an attractive targeting for their efficacy against infections caused by multi-resistant Gram-positive and Gram-negative bacteria. Among the related FAS II enzymes, beta ketoacyl-acyl carrier protein synthase (KAS), is an essential target for novel antibacterial drug design. Five novel Ethyl-3-(4-substituted phenyl) propanoates have been synthesized, characterized and screened for antibacterial activity. The inhibitory activities against Escherichia coli b-ketoacyl-acyl carrier protein synthase III (ecKAS III) were investigated by molecular docking simulation. Compounds which posses both good inhibitory activity and well binding affinities were compared their antibacterial activities against gram negative and gram-positive bacterial strains were tested, expecting to exploit potent antibacterial agent with broad-spectrum antibiotics activity. Compounds 4b, 4c, 4d exhibits significant activity and ethyl-3-(4-chlorophenyl)propanaoate (4b) exhibits highest antibacterial activity against all the bacteria among the synthesized compounds.
format Articulo
Articulo
author Vasanthakumari, Pradeepchandran R.
Narasimha, Jayaveera K.
Rajarathnam, Vijaianand
Palani, Kumarnallasivan
Ramasamy, Venkatnarayanan
Ramaraj, Sivakumar
Panneerselvam, Arulraj
author_facet Vasanthakumari, Pradeepchandran R.
Narasimha, Jayaveera K.
Rajarathnam, Vijaianand
Palani, Kumarnallasivan
Ramasamy, Venkatnarayanan
Ramaraj, Sivakumar
Panneerselvam, Arulraj
author_sort Vasanthakumari, Pradeepchandran R.
title Synthesis, antibacterial activities and molecular docking studies of ethyl 3-(4-substituted phenyl) propanoates as targeted antibiotics
title_short Synthesis, antibacterial activities and molecular docking studies of ethyl 3-(4-substituted phenyl) propanoates as targeted antibiotics
title_full Synthesis, antibacterial activities and molecular docking studies of ethyl 3-(4-substituted phenyl) propanoates as targeted antibiotics
title_fullStr Synthesis, antibacterial activities and molecular docking studies of ethyl 3-(4-substituted phenyl) propanoates as targeted antibiotics
title_full_unstemmed Synthesis, antibacterial activities and molecular docking studies of ethyl 3-(4-substituted phenyl) propanoates as targeted antibiotics
title_sort synthesis, antibacterial activities and molecular docking studies of ethyl 3-(4-substituted phenyl) propanoates as targeted antibiotics
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8293
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_3.pdf
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bdutipo_str Repositorios
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