Mucoadhesive microcapsules of glipizide formulated with gum kondagogu: in vitro and in vivo evaluation

Mucoadhesive microcapsules are proposed for the antidiabetic drug glipizide, to obtain controlled release. Glipizide microcapsules with a coat consisting of alginate and gum kondagogu were prepared by employing ionic gelation process and emulsification ionotropic gelation process. The microcapsules...

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Detalles Bibliográficos
Autores principales:	Raparla, Rama K., Talasila, Eswara G.K.M., Mankala, Santhosh K., Mayuren, Candasamy
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Sistemas de Liberación de Medicamentos ionic gelation; ionotropic gelation; mucoadhesion; hypoglycemic activity; in vitro; in vivo; controlled release Glipizida
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8291 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_1.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Sistemas de Liberación de Medicamentos ionic gelation; ionotropic gelation; mucoadhesion; hypoglycemic activity; in vitro; in vivo; controlled release Glipizida
spellingShingle	Farmacia Sistemas de Liberación de Medicamentos ionic gelation; ionotropic gelation; mucoadhesion; hypoglycemic activity; in vitro; in vivo; controlled release Glipizida Raparla, Rama K. Talasila, Eswara G.K.M. Mankala, Santhosh K. Mayuren, Candasamy Mucoadhesive microcapsules of glipizide formulated with gum kondagogu: in vitro and in vivo evaluation
topic_facet	Farmacia Sistemas de Liberación de Medicamentos ionic gelation; ionotropic gelation; mucoadhesion; hypoglycemic activity; in vitro; in vivo; controlled release Glipizida
description	Mucoadhesive microcapsules are proposed for the antidiabetic drug glipizide, to obtain controlled release. Glipizide microcapsules with a coat consisting of alginate and gum kondagogu were prepared by employing ionic gelation process and emulsification ionotropic gelation process. The microcapsules were evaluated for flow properties, Carr’s index, Hausner factor, microencapsulation efficiency, drug release characteristics, surface characteristics, compatibility studies, mucoadhesive properties and in-vivo hypoglycemic activity. These two methods showed individual, large sized, free flowing spherical microcapsules without any interactions. Glipizide release from the microcapsules was slow and followed zero order kinetics and followed non–fickian release and depended on the coat: core ratio and the method employed in the preparation of microcapsules. Among the two methods emulsification ionotropic gelation method was found to be more suitable for slow and complete release of glipizide over a long period of time. These microcapsules exhibited good mucoadhesive property in the in vitro wash-off test. In vivo evaluation in rabbits demonstrated significant hypoglycemic effect of glipizide.
format	Articulo Articulo
author	Raparla, Rama K. Talasila, Eswara G.K.M. Mankala, Santhosh K. Mayuren, Candasamy
author_facet	Raparla, Rama K. Talasila, Eswara G.K.M. Mankala, Santhosh K. Mayuren, Candasamy
author_sort	Raparla, Rama K.
title	Mucoadhesive microcapsules of glipizide formulated with gum kondagogu: in vitro and in vivo evaluation
title_short	Mucoadhesive microcapsules of glipizide formulated with gum kondagogu: in vitro and in vivo evaluation
title_full	Mucoadhesive microcapsules of glipizide formulated with gum kondagogu: in vitro and in vivo evaluation
title_fullStr	Mucoadhesive microcapsules of glipizide formulated with gum kondagogu: in vitro and in vivo evaluation
title_full_unstemmed	Mucoadhesive microcapsules of glipizide formulated with gum kondagogu: in vitro and in vivo evaluation
title_sort	mucoadhesive microcapsules of glipizide formulated with gum kondagogu: in vitro and in vivo evaluation
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8291 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_1.pdf
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bdutipo_str	Repositorios
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Mucoadhesive microcapsules of glipizide formulated with gum kondagogu: in vitro and in vivo evaluation

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