Antihistaminic activity of Ricinus communis roots using clonidine induced catalepsy in mice

Clonidine, an α2 adrenoreceptor agonist, induces dose dependent catalepsy in mice, which releases histamine from mast cells which is responsible for different asthmatic conditions. Ricinus communis Linn (Euphorbiaceae) is a medicinal plant; root is sweetish and has been used traditionally in the tre...

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Detalles Bibliográficos
Autores principales: Taur, Dnyaneshwar J., Patil, Ravindra Y.
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
antihistamine; chlorpheniramine maleate; clonidine; Ricinus communis
Imidazolinas
Plantas Medicinales
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8286
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_2_5.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8286
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
antihistamine; chlorpheniramine maleate; clonidine; Ricinus communis
Imidazolinas
Plantas Medicinales
spellingShingle Farmacia
antihistamine; chlorpheniramine maleate; clonidine; Ricinus communis
Imidazolinas
Plantas Medicinales
Taur, Dnyaneshwar J.
Patil, Ravindra Y.
Antihistaminic activity of Ricinus communis roots using clonidine induced catalepsy in mice
topic_facet Farmacia
antihistamine; chlorpheniramine maleate; clonidine; Ricinus communis
Imidazolinas
Plantas Medicinales
description Clonidine, an α2 adrenoreceptor agonist, induces dose dependent catalepsy in mice, which releases histamine from mast cells which is responsible for different asthmatic conditions. Ricinus communis Linn (Euphorbiaceae) is a medicinal plant; root is sweetish and has been used traditionally in the treatment of inflammation, pain fever, asthma, bronchititis and leprosy. In present study ethanol extract of R. communis roots (ERCR) at doses 100, 125 and 150 mg/kg intraperitoneally was evaluated for antihistaminic activity using clonidine induced catalepsy in mice. Finding of investigation showed that chlorpheniramine maleate and ERCR inhibit clonidine induced catalepsy significantly P < 0.001 when compare to control group. Present study concludes that ERCR possesses antihistaminic activity.
format Articulo
Comunicacion
author Taur, Dnyaneshwar J.
Patil, Ravindra Y.
author_facet Taur, Dnyaneshwar J.
Patil, Ravindra Y.
author_sort Taur, Dnyaneshwar J.
title Antihistaminic activity of Ricinus communis roots using clonidine induced catalepsy in mice
title_short Antihistaminic activity of Ricinus communis roots using clonidine induced catalepsy in mice
title_full Antihistaminic activity of Ricinus communis roots using clonidine induced catalepsy in mice
title_fullStr Antihistaminic activity of Ricinus communis roots using clonidine induced catalepsy in mice
title_full_unstemmed Antihistaminic activity of Ricinus communis roots using clonidine induced catalepsy in mice
title_sort antihistaminic activity of ricinus communis roots using clonidine induced catalepsy in mice
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8286
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_2_5.pdf
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