Preparation and characterization of gellan-chitosan polyelectrolyte complex beads
The purpose of the present investigation was to prepare gellan-chitosan polyelectrolyte complex beads in one step and to explore the potential of the prepared beads in the oral delivery of metronidazole (log P = 0.0) and metronidazole benzoate (log P = 2.19). Beads were prepared by extruding aqueous...
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8279 http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_21.pdf |
| Aporte de: |
| id |
I19-R120-10915-8279 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia chitosan; controlled release; gellan gum; polyelectrolyte complex; site specific drug release |
| spellingShingle |
Farmacia chitosan; controlled release; gellan gum; polyelectrolyte complex; site specific drug release Dixit, Raghav Verma, Anurag Soni, Shashank Mishra, Arun K. Bansal, Ashok K. Pandit, Jayant K. Preparation and characterization of gellan-chitosan polyelectrolyte complex beads |
| topic_facet |
Farmacia chitosan; controlled release; gellan gum; polyelectrolyte complex; site specific drug release |
| description |
The purpose of the present investigation was to prepare gellan-chitosan polyelectrolyte complex beads in one step and to explore the potential of the prepared beads in the oral delivery of metronidazole (log P = 0.0) and metronidazole benzoate (log P = 2.19). Beads were prepared by extruding aqueous solution of gellan gum (with or without drugs) into chitosan solution in acetic acid pH adjusted to 3.5. Prepared beads exhibited poor encapsulation and burst release for metronidazole, while very high encapsulation and extended release was observed for metronidazole benzoate in simulated gastric fluid (SGF, pH 1.2). Incorporation of type A & B gelatin significantly improved the metronidazole encapsulation in the beads but the release pattern remained the same. Overall, gellan-chitosan beads showed poor retardant capacity of drug release for metronidazole whereas good retardant capacity was observed for metronidazole benzoate. |
| format |
Articulo Articulo |
| author |
Dixit, Raghav Verma, Anurag Soni, Shashank Mishra, Arun K. Bansal, Ashok K. Pandit, Jayant K. |
| author_facet |
Dixit, Raghav Verma, Anurag Soni, Shashank Mishra, Arun K. Bansal, Ashok K. Pandit, Jayant K. |
| author_sort |
Dixit, Raghav |
| title |
Preparation and characterization of gellan-chitosan polyelectrolyte complex beads |
| title_short |
Preparation and characterization of gellan-chitosan polyelectrolyte complex beads |
| title_full |
Preparation and characterization of gellan-chitosan polyelectrolyte complex beads |
| title_fullStr |
Preparation and characterization of gellan-chitosan polyelectrolyte complex beads |
| title_full_unstemmed |
Preparation and characterization of gellan-chitosan polyelectrolyte complex beads |
| title_sort |
preparation and characterization of gellan-chitosan polyelectrolyte complex beads |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8279 http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_21.pdf |
| work_keys_str_mv |
AT dixitraghav preparationandcharacterizationofgellanchitosanpolyelectrolytecomplexbeads AT vermaanurag preparationandcharacterizationofgellanchitosanpolyelectrolytecomplexbeads AT sonishashank preparationandcharacterizationofgellanchitosanpolyelectrolytecomplexbeads AT mishraarunk preparationandcharacterizationofgellanchitosanpolyelectrolytecomplexbeads AT bansalashokk preparationandcharacterizationofgellanchitosanpolyelectrolytecomplexbeads AT panditjayantk preparationandcharacterizationofgellanchitosanpolyelectrolytecomplexbeads |
| bdutipo_str |
Repositorios |
| _version_ |
1764820488631091200 |