Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina

The objective of this preliminary study was to describe alleles of bovine major histocompatibility complex class II BoLA-DRB3.2 gene associated with resistance and susceptibility to Persistent Lymphocytosis (PL) in Bovine leukaemia virus (BLV) infected cattle, to set a direction for the future studi...

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Autores principales:	Panei, Carlos Javier, Suzuki, Kuniaki, Echeverría, María Gabriela, Serena, María Soledad, Metz, Germán Ernesto, González, Ester Teresa
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2009
Materias:	Ciencias Veterinarias Holando-Argentino MHC Modelling PCR-RFLP South America
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/82781
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-82781
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Veterinarias Holando-Argentino MHC Modelling PCR-RFLP South America
spellingShingle	Ciencias Veterinarias Holando-Argentino MHC Modelling PCR-RFLP South America Panei, Carlos Javier Suzuki, Kuniaki Echeverría, María Gabriela Serena, María Soledad Metz, Germán Ernesto González, Ester Teresa Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
topic_facet	Ciencias Veterinarias Holando-Argentino MHC Modelling PCR-RFLP South America
description	The objective of this preliminary study was to describe alleles of bovine major histocompatibility complex class II BoLA-DRB3.2 gene associated with resistance and susceptibility to Persistent Lymphocytosis (PL) in Bovine leukaemia virus (BLV) infected cattle, to set a direction for the future studies. A total of 81 dairy cattle in Argentina were investigated for the distribution of BoLA-DRB3.2 alleles. The study cattle were categorized into 3 groups as follows: Category PL+ (BLV seropositive with PL); Category PL- (BLV seropositive without PL) and Category BLV- (BLV seronegative). The alleles were identified by polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism. The association between the BoLA-DRB3.2 alleles and the PL+ and PL- categories was determined as the odds ratio. Some alleles BoLA-DRB3.2 mediating (1) resistance and (2) susceptibility to PL were observed, respectively. A stochastic model including Shannon's diversity index calculation was run based on Markov-Chain Monte Carlo simulation method. The Shannon's diversity indices in each of the cattle categories indicated that the richness of gene diversity decreased as leading to a clinical stage of BLV. This relates to the existence of alleles mediating resistance and susceptibility to PL. The stochastic prediction with inclusion of uncertainty is important which can serve as a future study beacon.
format	Articulo Articulo
author	Panei, Carlos Javier Suzuki, Kuniaki Echeverría, María Gabriela Serena, María Soledad Metz, Germán Ernesto González, Ester Teresa
author_facet	Panei, Carlos Javier Suzuki, Kuniaki Echeverría, María Gabriela Serena, María Soledad Metz, Germán Ernesto González, Ester Teresa
author_sort	Panei, Carlos Javier
title	Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_short	Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_full	Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_fullStr	Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_full_unstemmed	Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_sort	association of bola-drb3.2 alleles with resistance and susceptibility to persistent lymphocytosis in blv infected cattle in argentina
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/82781
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bdutipo_str	Repositorios
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Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina

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