Studies on in-vitro transcutaneous delivery of losartan potassium, influence of penetration enhancers and barrier membrane

Formulation and in vitro evaluation of losartan potassium (LP) loaded transdermal delivery system (TDS) was investigated for controlled release and improved therapeutic efficacy. TDS (patches) were prepared by varying the composition of Eudragit RL 100 and Eudragit RS 100 (5:0, 4:1, 3:2, 2.5:2.5, 2:...

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Detalles Bibliográficos
Autores principales:	Petkar, Kailash C., Pore, Yogesh V., Kuchekar, Bhanudas S.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Hipertensión capsaicin; eudragit; losartan potassium; pluronic F-68; sex; skin; transdermal delivery Sistemas de Liberación de Medicamentos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8278 http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_20.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8278
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Hipertensión capsaicin; eudragit; losartan potassium; pluronic F-68; sex; skin; transdermal delivery Sistemas de Liberación de Medicamentos
spellingShingle	Farmacia Hipertensión capsaicin; eudragit; losartan potassium; pluronic F-68; sex; skin; transdermal delivery Sistemas de Liberación de Medicamentos Petkar, Kailash C. Pore, Yogesh V. Kuchekar, Bhanudas S. Studies on in-vitro transcutaneous delivery of losartan potassium, influence of penetration enhancers and barrier membrane
topic_facet	Farmacia Hipertensión capsaicin; eudragit; losartan potassium; pluronic F-68; sex; skin; transdermal delivery Sistemas de Liberación de Medicamentos
description	Formulation and in vitro evaluation of losartan potassium (LP) loaded transdermal delivery system (TDS) was investigated for controlled release and improved therapeutic efficacy. TDS (patches) were prepared by varying the composition of Eudragit RL 100 and Eudragit RS 100 (5:0, 4:1, 3:2, 2.5:2.5, 2:3, 1:4 and 0:5). Patches were evaluated for thickness, content uniformity, mechanical properties, moisture uptake and in vitro drug release. Technological parameters for all the formulations were found to be within the limit. In vitro studies showed relatively high permeation of LP (F1- 42.17 ± 1.13 %) from the formulation comprising 4:1 ratio of polymer. Inclusion of capsaicin (55.70 ± 1.55 %) and pluronic F-68 (70.88 ± 1.20 %) to formulation F1 resulted increased permeation of LP across human skin. In conclusion, this study demonstrated the potential of simple transdermal adhesive patch incorporating LP to deliver therapeutically useful dose in-vivo for the treatment of hypertension.
format	Articulo Articulo
author	Petkar, Kailash C. Pore, Yogesh V. Kuchekar, Bhanudas S.
author_facet	Petkar, Kailash C. Pore, Yogesh V. Kuchekar, Bhanudas S.
author_sort	Petkar, Kailash C.
title	Studies on in-vitro transcutaneous delivery of losartan potassium, influence of penetration enhancers and barrier membrane
title_short	Studies on in-vitro transcutaneous delivery of losartan potassium, influence of penetration enhancers and barrier membrane
title_full	Studies on in-vitro transcutaneous delivery of losartan potassium, influence of penetration enhancers and barrier membrane
title_fullStr	Studies on in-vitro transcutaneous delivery of losartan potassium, influence of penetration enhancers and barrier membrane
title_full_unstemmed	Studies on in-vitro transcutaneous delivery of losartan potassium, influence of penetration enhancers and barrier membrane
title_sort	studies on in-vitro transcutaneous delivery of losartan potassium, influence of penetration enhancers and barrier membrane
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8278 http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_20.pdf
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bdutipo_str	Repositorios
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Studies on in-vitro transcutaneous delivery of losartan potassium, influence of penetration enhancers and barrier membrane

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