Evolution of adherence to antiretroviral treatment in a spanish hospital during 2001, 2005 and 2008

The aim of this study was to analyze the evolution of adherence to highly active antiretroviral therapy (HAART) in the Hospital General Universitario Gregorio Marañón (Madrid, Spain) over the last 8 years and determine the variables associated with the complexity of treatment and suboptimal adherenc...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Echarri Martínez, Lara, Rodríguez González, Carmen G., Castillo Romera, Isabel, Trovato López, Nicolás, Ais Larisgoitia, Arantza, Bellón Cano, José M., Sanjurjo Sáez, María
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
adherence antiretroviral therapy; HAART; predictive factors
Terapia Antirretroviral Altamente Activa
Hospitales
Resultado del Tratamiento
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8277
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_19.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8277
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
adherence antiretroviral therapy; HAART; predictive factors
Terapia Antirretroviral Altamente Activa
Hospitales
Resultado del Tratamiento
spellingShingle Farmacia
adherence antiretroviral therapy; HAART; predictive factors
Terapia Antirretroviral Altamente Activa
Hospitales
Resultado del Tratamiento
Echarri Martínez, Lara
Rodríguez González, Carmen G.
Castillo Romera, Isabel
Trovato López, Nicolás
Ais Larisgoitia, Arantza
Bellón Cano, José M.
Sanjurjo Sáez, María
Evolution of adherence to antiretroviral treatment in a spanish hospital during 2001, 2005 and 2008
topic_facet Farmacia
adherence antiretroviral therapy; HAART; predictive factors
Terapia Antirretroviral Altamente Activa
Hospitales
Resultado del Tratamiento
description The aim of this study was to analyze the evolution of adherence to highly active antiretroviral therapy (HAART) in the Hospital General Universitario Gregorio Marañón (Madrid, Spain) over the last 8 years and determine the variables associated with the complexity of treatment and suboptimal adherence. An observational, retrospective method was used to measure adherence during the first 6 months of HAART in 3 cohorts: 2001 cohort (n = 90), 2005 cohort (n = 98), and 2008 cohort (n = 110). The adherence rate was determined using 2 methods: Pharmacy Department dispensation records and virologic response data. The evolution of the complexity of treatment and its influence on the adherence rate was analyzed by logistic regression. Adherence to HAART increased progressively from 45.6 % in 2001 to 56.1 % in 2005 and 77.3 % in 2008. Statistically significant differences were only observed between cohorts in 2005 and 2008. The average daily pill burden was 7, 4, and 4.5 tablets, respectively. The percentage of patients on twice-daily regimens decreased from 93.3 % in 2001 to 63.6 % in 2008, with a parallel increase in once-daily regimens. The proportion of patients with dietary restrictions decreased from 24.4 % to 3.6 %. A statistically significant association was found between the number of medication units per day and adherence and between frequency of administration and adherence. Adherence to HAART has improved significantly in the last 8 years. While the complexity of the treatment was significantly reduced in 2005, the largest increase in adherence occurred in the last cohort, which shows the influence of factors other than treatment simplification.
format Articulo
Articulo
author Echarri Martínez, Lara
Rodríguez González, Carmen G.
Castillo Romera, Isabel
Trovato López, Nicolás
Ais Larisgoitia, Arantza
Bellón Cano, José M.
Sanjurjo Sáez, María
author_facet Echarri Martínez, Lara
Rodríguez González, Carmen G.
Castillo Romera, Isabel
Trovato López, Nicolás
Ais Larisgoitia, Arantza
Bellón Cano, José M.
Sanjurjo Sáez, María
author_sort Echarri Martínez, Lara
title Evolution of adherence to antiretroviral treatment in a spanish hospital during 2001, 2005 and 2008
title_short Evolution of adherence to antiretroviral treatment in a spanish hospital during 2001, 2005 and 2008
title_full Evolution of adherence to antiretroviral treatment in a spanish hospital during 2001, 2005 and 2008
title_fullStr Evolution of adherence to antiretroviral treatment in a spanish hospital during 2001, 2005 and 2008
title_full_unstemmed Evolution of adherence to antiretroviral treatment in a spanish hospital during 2001, 2005 and 2008
title_sort evolution of adherence to antiretroviral treatment in a spanish hospital during 2001, 2005 and 2008
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8277
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_19.pdf
work_keys_str_mv AT echarrimartinezlara evolutionofadherencetoantiretroviraltreatmentinaspanishhospitalduring20012005and2008
AT rodriguezgonzalezcarmeng evolutionofadherencetoantiretroviraltreatmentinaspanishhospitalduring20012005and2008
AT castilloromeraisabel evolutionofadherencetoantiretroviraltreatmentinaspanishhospitalduring20012005and2008
AT trovatolopeznicolas evolutionofadherencetoantiretroviraltreatmentinaspanishhospitalduring20012005and2008
AT aislarisgoitiaarantza evolutionofadherencetoantiretroviraltreatmentinaspanishhospitalduring20012005and2008
AT belloncanojosem evolutionofadherencetoantiretroviraltreatmentinaspanishhospitalduring20012005and2008
AT sanjurjosaezmaria evolutionofadherencetoantiretroviraltreatmentinaspanishhospitalduring20012005and2008
bdutipo_str Repositorios
_version_ 1764820488609071110

Ejemplares similares