Comparative study on the pharmacokinetic of lansoprazole in gastric ulcer and normal rabbits by HPLC-DAD

Gastric ulcer is one of ulcerous diseases and may result in some changes of many enzymes and transporters concerned with metabolism and disposal of drug. The pharmacokinetic of drug should be different between peptic ulcer and normal animals. Lansoprazole has been one of important medicine for treat...

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Autores principales: Jiang, Xianglan, Wu, Jing, Tang, Daoquan, Gao, Yuanyuan, Yang, Dongzhi, Zhao, Ziming, Chen, Hui
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Enfermedades Gastrointestinales
gastric ulcer; high-performance liquid chromatography; lansoprazole; pharmacokinetics
Inhibidores de la Bomba de Protones
Cromatografía
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8274
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_16.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8274
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Enfermedades Gastrointestinales
gastric ulcer; high-performance liquid chromatography; lansoprazole; pharmacokinetics
Inhibidores de la Bomba de Protones
Cromatografía
spellingShingle Farmacia
Enfermedades Gastrointestinales
gastric ulcer; high-performance liquid chromatography; lansoprazole; pharmacokinetics
Inhibidores de la Bomba de Protones
Cromatografía
Jiang, Xianglan
Wu, Jing
Tang, Daoquan
Gao, Yuanyuan
Yang, Dongzhi
Zhao, Ziming
Chen, Hui
Comparative study on the pharmacokinetic of lansoprazole in gastric ulcer and normal rabbits by HPLC-DAD
topic_facet Farmacia
Enfermedades Gastrointestinales
gastric ulcer; high-performance liquid chromatography; lansoprazole; pharmacokinetics
Inhibidores de la Bomba de Protones
Cromatografía
description Gastric ulcer is one of ulcerous diseases and may result in some changes of many enzymes and transporters concerned with metabolism and disposal of drug. The pharmacokinetic of drug should be different between peptic ulcer and normal animals. Lansoprazole has been one of important medicine for treatment of ulcerous diseases. So, this paper investigated the difference of pharmacokinetic profiles of lansoprazole in gastric ulcer and normal rabbits in vivo by HPLC-DAD method. In this work, a liquid-liquid extraction and enrichment method with RP-HPLC determination route was taken. The pharmacokinetic parameters were analyzed by double-compartmental method (DAS2.0). The pharmacokinetic parameters of lansoprazole in normal and ulcer rabbits were as follows: (614.42 ± 152.25) and (875.73 ± 316.34) mg h/L for AUC(<sub>0-6.5</sub>); (0.68 ± 0.12) and (0.83 ± 0.22) h for MRT(<sub>0-6.5</sub>), (0.52 ± 0.23) and (0.87 ± 0.42) h for t<sub>1/2</sub> ; (6.13 ± 2.11) and (2.54 ± 1.65) L/h/kg for CL, respectively
format Articulo
Articulo
author Jiang, Xianglan
Wu, Jing
Tang, Daoquan
Gao, Yuanyuan
Yang, Dongzhi
Zhao, Ziming
Chen, Hui
author_facet Jiang, Xianglan
Wu, Jing
Tang, Daoquan
Gao, Yuanyuan
Yang, Dongzhi
Zhao, Ziming
Chen, Hui
author_sort Jiang, Xianglan
title Comparative study on the pharmacokinetic of lansoprazole in gastric ulcer and normal rabbits by HPLC-DAD
title_short Comparative study on the pharmacokinetic of lansoprazole in gastric ulcer and normal rabbits by HPLC-DAD
title_full Comparative study on the pharmacokinetic of lansoprazole in gastric ulcer and normal rabbits by HPLC-DAD
title_fullStr Comparative study on the pharmacokinetic of lansoprazole in gastric ulcer and normal rabbits by HPLC-DAD
title_full_unstemmed Comparative study on the pharmacokinetic of lansoprazole in gastric ulcer and normal rabbits by HPLC-DAD
title_sort comparative study on the pharmacokinetic of lansoprazole in gastric ulcer and normal rabbits by hplc-dad
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8274
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_16.pdf
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