Fast disintegrating tablets of flurbiprofen: formulation and characterization

The purpose of development oral fast disintegrating drug delivery is not only to give fast relief but also to overcome difficulty in swallowing tablets and capsules, resulting in non-compliance and ineffective therapy. The aim of present study is to formulate fast disintegrating of flurbiprofen by u...

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Detalles Bibliográficos
Autores principales: Vemula, Sateesh K., Veerareddy, Prabhakar Reddy
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Flurbiprofeno
fast disintegrating drug delivery; pre-compression parameters; post-compression parameters; superdisintegrants
Sistemas de Liberación de Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8272
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_14.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8272
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Flurbiprofeno
fast disintegrating drug delivery; pre-compression parameters; post-compression parameters; superdisintegrants
Sistemas de Liberación de Medicamentos
spellingShingle Farmacia
Flurbiprofeno
fast disintegrating drug delivery; pre-compression parameters; post-compression parameters; superdisintegrants
Sistemas de Liberación de Medicamentos
Vemula, Sateesh K.
Veerareddy, Prabhakar Reddy
Fast disintegrating tablets of flurbiprofen: formulation and characterization
topic_facet Farmacia
Flurbiprofeno
fast disintegrating drug delivery; pre-compression parameters; post-compression parameters; superdisintegrants
Sistemas de Liberación de Medicamentos
description The purpose of development oral fast disintegrating drug delivery is not only to give fast relief but also to overcome difficulty in swallowing tablets and capsules, resulting in non-compliance and ineffective therapy. The aim of present study is to formulate fast disintegrating of flurbiprofen by using superdisintegrants. Flurbiprofen fast disintegrating tablets were prepared by using direct compression method and were characterized for both pre-compression parameters and post-compression parameters to comply with pharmacopoeial limits. From the in vitro drug release studies the optimized formulation showed almost complete drug release (above 99 %) within 15 min. DSC and FTIR studies were carried out to understand the drug-polymer compatibility and revealed that there was no possible interaction between them. Thus developed fast disintegrating tablets may be suitable to give rapid drug delivery and rapid onset of action.
format Articulo
Articulo
author Vemula, Sateesh K.
Veerareddy, Prabhakar Reddy
author_facet Vemula, Sateesh K.
Veerareddy, Prabhakar Reddy
author_sort Vemula, Sateesh K.
title Fast disintegrating tablets of flurbiprofen: formulation and characterization
title_short Fast disintegrating tablets of flurbiprofen: formulation and characterization
title_full Fast disintegrating tablets of flurbiprofen: formulation and characterization
title_fullStr Fast disintegrating tablets of flurbiprofen: formulation and characterization
title_full_unstemmed Fast disintegrating tablets of flurbiprofen: formulation and characterization
title_sort fast disintegrating tablets of flurbiprofen: formulation and characterization
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8272
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_14.pdf
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AT veerareddyprabhakarreddy fastdisintegratingtabletsofflurbiprofenformulationandcharacterization
bdutipo_str Repositorios
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