Antimicrobial, antioxidant, and cytotoxic activities of Bixa orellana Linn

Bixa orellana Linn., commonly known as "lipstick plant", is used in folk medicines to treat infections of microbial origin as well as coloring agents in food stuffs in the LDCs like Bangladesh. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the w...

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Autores principales: Ul Islam, S.M. Bakhtiar, Hossain, Khalid, Gomes, Isidore, Gomes, Donald J., Rahman, Sabita Rezwana, Rahman, Mohammad S., Rashid, Mohammad A.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Plantas Medicinales
antioxidant capacity; Bixa orellana Linn; brine shrimp lethality bioassay; multidrug resistant (MDR) bacteria; total phenolic content
Técnicas de Química Analítica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8271
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_13.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8271
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Plantas Medicinales
antioxidant capacity; Bixa orellana Linn; brine shrimp lethality bioassay; multidrug resistant (MDR) bacteria; total phenolic content
Técnicas de Química Analítica
spellingShingle Farmacia
Plantas Medicinales
antioxidant capacity; Bixa orellana Linn; brine shrimp lethality bioassay; multidrug resistant (MDR) bacteria; total phenolic content
Técnicas de Química Analítica
Ul Islam, S.M. Bakhtiar
Hossain, Khalid
Gomes, Isidore
Gomes, Donald J.
Rahman, Sabita Rezwana
Rahman, Mohammad S.
Rashid, Mohammad A.
Antimicrobial, antioxidant, and cytotoxic activities of Bixa orellana Linn
topic_facet Farmacia
Plantas Medicinales
antioxidant capacity; Bixa orellana Linn; brine shrimp lethality bioassay; multidrug resistant (MDR) bacteria; total phenolic content
Técnicas de Química Analítica
description Bixa orellana Linn., commonly known as "lipstick plant", is used in folk medicines to treat infections of microbial origin as well as coloring agents in food stuffs in the LDCs like Bangladesh. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the warm water extract of leaves of B. orellana were evaluated against 25 multidrug resistant (MDR) clinical isolates and 6 food-borne pathogens using the micro-dilution broth method modified to comply with the NCCLS standards. The total phenolic content and antioxidant capacity of warm water, ethanol, and methanol extracts of the seeds and leaves of B. orellana were also evaluated. The brine shrimp lethality assay was conducted to assess the toxicity of the extracts. Except Pseudomonas spp., all the MDR isolates and food-borne pathogens tested were susceptible to the warm water extract of the leaves. The MIC and MBC ranged between 8-256 μg/mL and 16 - 256 μg/mL, respectively. Among the test organisms, Streptococcus spp. and Shigella dysenteriae-1 MJ-84 showed highest susceptibility while Escherichia coli exhibited moderate susceptibility to warm water extract of the leaves. The highest total phenolic content (99.99 mg of GAE/g of extractives) and antioxidant capacity (IC<sub>50</sub> value 13 μg/mL) were observed in ethanolic extract of seeds of B. orellana, whereas the IC<sub>50</sub> of the reference standard BHT (tert-butyl-1-hydroxytoluene) was 59.2 μg/mL. On the other hand, in the brine shrimp lethality bioassay the methanolic extract of the seeds of B. orellana demonstrated strong cytotoxic activity with IC<sub>50</sub> value of 19.3 μg/mL. These results suggest that the extracts of B. orellana possess bioactive compounds
format Articulo
Articulo
author Ul Islam, S.M. Bakhtiar
Hossain, Khalid
Gomes, Isidore
Gomes, Donald J.
Rahman, Sabita Rezwana
Rahman, Mohammad S.
Rashid, Mohammad A.
author_facet Ul Islam, S.M. Bakhtiar
Hossain, Khalid
Gomes, Isidore
Gomes, Donald J.
Rahman, Sabita Rezwana
Rahman, Mohammad S.
Rashid, Mohammad A.
author_sort Ul Islam, S.M. Bakhtiar
title Antimicrobial, antioxidant, and cytotoxic activities of Bixa orellana Linn
title_short Antimicrobial, antioxidant, and cytotoxic activities of Bixa orellana Linn
title_full Antimicrobial, antioxidant, and cytotoxic activities of Bixa orellana Linn
title_fullStr Antimicrobial, antioxidant, and cytotoxic activities of Bixa orellana Linn
title_full_unstemmed Antimicrobial, antioxidant, and cytotoxic activities of Bixa orellana Linn
title_sort antimicrobial, antioxidant, and cytotoxic activities of bixa orellana linn
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8271
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_13.pdf
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