Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients

The aim of the present study was to develop sustained release swelling tablets containing metformin HCl and confine them into the stomach for enhancement of bioavailability. The different batches were manufactured by wet granulation method with HPMC K200M and HPMC K100M in combination using Minipres...

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Detalles Bibliográficos
Autores principales: Ige, Pradum P., Gattani, Surendra G.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
gastric retention; hydroxy propyl methyl cellulose K200M; metformin HCl; swelling matrix tablets; type 2 diabetes mellitus
Enfermedades del Sistema Endocrino
Sistemas de Liberación de Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8270
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_12.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8270
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
gastric retention; hydroxy propyl methyl cellulose K200M; metformin HCl; swelling matrix tablets; type 2 diabetes mellitus
Enfermedades del Sistema Endocrino
Sistemas de Liberación de Medicamentos
spellingShingle Farmacia
gastric retention; hydroxy propyl methyl cellulose K200M; metformin HCl; swelling matrix tablets; type 2 diabetes mellitus
Enfermedades del Sistema Endocrino
Sistemas de Liberación de Medicamentos
Ige, Pradum P.
Gattani, Surendra G.
Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
topic_facet Farmacia
gastric retention; hydroxy propyl methyl cellulose K200M; metformin HCl; swelling matrix tablets; type 2 diabetes mellitus
Enfermedades del Sistema Endocrino
Sistemas de Liberación de Medicamentos
description The aim of the present study was to develop sustained release swelling tablets containing metformin HCl and confine them into the stomach for enhancement of bioavailability. The different batches were manufactured by wet granulation method with HPMC K200M and HPMC K100M in combination using Minipress and characterized by Fourier Transform Infra-Red spectroscopy, differential scanning calorimetry, x-ray diffraction, mucoadhesion, swelling, erosion and in vitro drug release. The optimized formulation F8 shows the 4 fold and F2 & F11 shows the 3 fold swelling. Mucoadhesion strength and ex-vivo retention time of F8 was found to have 128.47 grams and 9.23 h, respectively. The F2, F8 and F11 were proved to be an expandable GRDF and showed case II diffusion mechanism with optimum erosion. The in vitro drug release, mucoadhesion, swelling, erosion and ex-vivo retention time evidences were concluded that retention of tablets in stomach up to 14 h and sustained release of drug.
format Articulo
Articulo
author Ige, Pradum P.
Gattani, Surendra G.
author_facet Ige, Pradum P.
Gattani, Surendra G.
author_sort Ige, Pradum P.
title Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
title_short Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
title_full Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
title_fullStr Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
title_full_unstemmed Design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
title_sort design, development and in vitro evaluation of swelling gastro retentive drug delivery system for type 2 diabetic patients
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8270
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_12.pdf
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AT gattanisurendrag designdevelopmentandinvitroevaluationofswellinggastroretentivedrugdeliverysystemfortype2diabeticpatients
bdutipo_str Repositorios
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