Preventive effects of atorvastatin on atherosclerosis in experimental rabbits are associated with reduction in cholesterol level and VCAM-1 expression

In this study, blood samples of rabbits were collected to measure plasma total cholesterol, total triglyceride, and LDL-cholesterol. After 16 weeks of high cholesterol diet with or without atorvastatin treatment, the rabbits were sacrificed and morphological changes in tissues were examined with hem...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yu, Lei, Ling, Qin, Rui, Qu, Jiaying, Zhang
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
atorvastatin; atherosclerosis; inflammation; statin; VCAM-1
Colesterol
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8264
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_6.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8264
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
atorvastatin; atherosclerosis; inflammation; statin; VCAM-1
Colesterol
spellingShingle Farmacia
atorvastatin; atherosclerosis; inflammation; statin; VCAM-1
Colesterol
Yu, Lei
Ling, Qin
Rui, Qu
Jiaying, Zhang
Preventive effects of atorvastatin on atherosclerosis in experimental rabbits are associated with reduction in cholesterol level and VCAM-1 expression
topic_facet Farmacia
atorvastatin; atherosclerosis; inflammation; statin; VCAM-1
Colesterol
description In this study, blood samples of rabbits were collected to measure plasma total cholesterol, total triglyceride, and LDL-cholesterol. After 16 weeks of high cholesterol diet with or without atorvastatin treatment, the rabbits were sacrificed and morphological changes in tissues were examined with hematoxylin and eosin (HE) staining, and the expression of vascular-cell adhesion molecule 1 (VCAM-1) was determined by immunostaining and reverse transcription-polymerase chain reaction (RT-PCR). We demonstrate that atorvastatin significantly reduced plasma levels of total cholesterol (41.7 %) and LDLcholesterol (34.6 %). Neither the hyper cholesterol diet nor atorvastatin treatment had any significant impact on body weight and plasma triglycerides (TG). Atorvastatin significantly restored the intima with widening of 40.9 % and even down-regulated the ratio of intima/media by 55.5 %. The inhibitory effects of atorvastatin on the expression of VCAM-1 showed a decrease of up to 46.9 % (P < 0.01). The diseased rabbits showed a 63.2 % increase in VCAM-1 mRNA expression (P < 0.01), which was reversed by nearly 60 % by treatment with atorvastatin
format Articulo
Articulo
author Yu, Lei
Ling, Qin
Rui, Qu
Jiaying, Zhang
author_facet Yu, Lei
Ling, Qin
Rui, Qu
Jiaying, Zhang
author_sort Yu, Lei
title Preventive effects of atorvastatin on atherosclerosis in experimental rabbits are associated with reduction in cholesterol level and VCAM-1 expression
title_short Preventive effects of atorvastatin on atherosclerosis in experimental rabbits are associated with reduction in cholesterol level and VCAM-1 expression
title_full Preventive effects of atorvastatin on atherosclerosis in experimental rabbits are associated with reduction in cholesterol level and VCAM-1 expression
title_fullStr Preventive effects of atorvastatin on atherosclerosis in experimental rabbits are associated with reduction in cholesterol level and VCAM-1 expression
title_full_unstemmed Preventive effects of atorvastatin on atherosclerosis in experimental rabbits are associated with reduction in cholesterol level and VCAM-1 expression
title_sort preventive effects of atorvastatin on atherosclerosis in experimental rabbits are associated with reduction in cholesterol level and vcam-1 expression
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8264
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_6.pdf
work_keys_str_mv AT yulei preventiveeffectsofatorvastatinonatherosclerosisinexperimentalrabbitsareassociatedwithreductionincholesterollevelandvcam1expression
AT lingqin preventiveeffectsofatorvastatinonatherosclerosisinexperimentalrabbitsareassociatedwithreductionincholesterollevelandvcam1expression
AT ruiqu preventiveeffectsofatorvastatinonatherosclerosisinexperimentalrabbitsareassociatedwithreductionincholesterollevelandvcam1expression
AT jiayingzhang preventiveeffectsofatorvastatinonatherosclerosisinexperimentalrabbitsareassociatedwithreductionincholesterollevelandvcam1expression
bdutipo_str Repositorios
_version_ 1764820488470659078

Ejemplares similares