Development and release kinetics of a novel formulation of nimesulide prepared by microencapsulation using synthetic polymers

The synthetic polymers and their combinations were employed to retard the release of nimesulide from microcapsules. Microcapsules were prepared in different ratios of Eudragit RL 100 and hydroxy propyl methyl cellulose (HPMC) separately and in combination. All formulations of microcapsules were comp...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ranjha, Nazar M., Iqbal, Furqan, Madni, Asadullah, Usman, Muhammad, Ahmad, Mahmood, Aamir, Muhammad N.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
eudragit; HPMC; microencapsulation; nimesulide; release kinetics
Agentes Antiinflamatorios no Esteroides
Sistemas de Liberación de Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8263
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_5.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8263
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
eudragit; HPMC; microencapsulation; nimesulide; release kinetics
Agentes Antiinflamatorios no Esteroides
Sistemas de Liberación de Medicamentos
spellingShingle Farmacia
eudragit; HPMC; microencapsulation; nimesulide; release kinetics
Agentes Antiinflamatorios no Esteroides
Sistemas de Liberación de Medicamentos
Ranjha, Nazar M.
Iqbal, Furqan
Madni, Asadullah
Usman, Muhammad
Ahmad, Mahmood
Aamir, Muhammad N.
Development and release kinetics of a novel formulation of nimesulide prepared by microencapsulation using synthetic polymers
topic_facet Farmacia
eudragit; HPMC; microencapsulation; nimesulide; release kinetics
Agentes Antiinflamatorios no Esteroides
Sistemas de Liberación de Medicamentos
description The synthetic polymers and their combinations were employed to retard the release of nimesulide from microcapsules. Microcapsules were prepared in different ratios of Eudragit RL 100 and hydroxy propyl methyl cellulose (HPMC) separately and in combination. All formulations of microcapsules were compressed to tablets. Dissolution of microcapsules and their tablets was performed by USP-apparatus-II in 900 mL borate buffer of pH 8.4 at 37.0 ± 0.5 ºC, at 50 rpm. In vitro kinetics was determined by various models including Zero order, First Order, Higuchi, Korsmeyer-Peppas and Hixson-Crowell. Eudragit showed higher retarding effect over extended period of time on release of drug than HPMC alone or its combination with Eudragit.
format Articulo
Articulo
author Ranjha, Nazar M.
Iqbal, Furqan
Madni, Asadullah
Usman, Muhammad
Ahmad, Mahmood
Aamir, Muhammad N.
author_facet Ranjha, Nazar M.
Iqbal, Furqan
Madni, Asadullah
Usman, Muhammad
Ahmad, Mahmood
Aamir, Muhammad N.
author_sort Ranjha, Nazar M.
title Development and release kinetics of a novel formulation of nimesulide prepared by microencapsulation using synthetic polymers
title_short Development and release kinetics of a novel formulation of nimesulide prepared by microencapsulation using synthetic polymers
title_full Development and release kinetics of a novel formulation of nimesulide prepared by microencapsulation using synthetic polymers
title_fullStr Development and release kinetics of a novel formulation of nimesulide prepared by microencapsulation using synthetic polymers
title_full_unstemmed Development and release kinetics of a novel formulation of nimesulide prepared by microencapsulation using synthetic polymers
title_sort development and release kinetics of a novel formulation of nimesulide prepared by microencapsulation using synthetic polymers
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8263
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_5.pdf
work_keys_str_mv AT ranjhanazarm developmentandreleasekineticsofanovelformulationofnimesulidepreparedbymicroencapsulationusingsyntheticpolymers
AT iqbalfurqan developmentandreleasekineticsofanovelformulationofnimesulidepreparedbymicroencapsulationusingsyntheticpolymers
AT madniasadullah developmentandreleasekineticsofanovelformulationofnimesulidepreparedbymicroencapsulationusingsyntheticpolymers
AT usmanmuhammad developmentandreleasekineticsofanovelformulationofnimesulidepreparedbymicroencapsulationusingsyntheticpolymers
AT ahmadmahmood developmentandreleasekineticsofanovelformulationofnimesulidepreparedbymicroencapsulationusingsyntheticpolymers
AT aamirmuhammadn developmentandreleasekineticsofanovelformulationofnimesulidepreparedbymicroencapsulationusingsyntheticpolymers
bdutipo_str Repositorios
_version_ 1764820488463319041

Ejemplares similares