Influence of cellulose derivatives and natural polymers on in vitro release kinetics of metoprolol succinate from extended release matrix tablets

In the present investigation, extended release tablets of metoprolol succinate were developed using cellulose derivatives and natural gums as matrix formers and were evaluated for its extended release characteristics. The optimized formulation (F7) was obtained using cellulose derivatives in the rat...

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Detalles Bibliográficos
Autores principales:	Sunil, R., Somagoni, Jagan M., Panakanti, Pavan K., Ega, Chandra M., Yamsani, Madhusudan R.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Celulosa hydroxypropyl methylcellulose; metoprolol succinate; sodium CMC; sustained release matrix tablets Polímeros Cinética
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8262 http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_4.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8262
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Celulosa hydroxypropyl methylcellulose; metoprolol succinate; sodium CMC; sustained release matrix tablets Polímeros Cinética
spellingShingle	Farmacia Celulosa hydroxypropyl methylcellulose; metoprolol succinate; sodium CMC; sustained release matrix tablets Polímeros Cinética Sunil, R. Somagoni, Jagan M. Panakanti, Pavan K. Ega, Chandra M. Yamsani, Madhusudan R. Influence of cellulose derivatives and natural polymers on in vitro release kinetics of metoprolol succinate from extended release matrix tablets
topic_facet	Farmacia Celulosa hydroxypropyl methylcellulose; metoprolol succinate; sodium CMC; sustained release matrix tablets Polímeros Cinética
description	In the present investigation, extended release tablets of metoprolol succinate were developed using cellulose derivatives and natural gums as matrix formers and were evaluated for its extended release characteristics. The optimized formulation (F7) was obtained using cellulose derivatives in the ratio of 1:0.5:1drug, HPMC K 100M and Na CMC, respectively. Prepared tablets were subjected to all the Pharmacopeial quality tests and found to be in the limits. The in vitro release studies of prepared matrix tablets with both the polymers were also studied. The kinetic treatment illustrate that the optimized formulation (F7) followed zero order kinetics with release exponent (n) 0.82 and showed good stability as per ICH guidelines. FT-IR and DSC studies indicated no chemical interaction between the drug and excipients. Oral extended release tablets of metoprolol succinate could be successfully prepared using an appropriate combination of cellulose polymers when compared with natural gums
format	Articulo Articulo
author	Sunil, R. Somagoni, Jagan M. Panakanti, Pavan K. Ega, Chandra M. Yamsani, Madhusudan R.
author_facet	Sunil, R. Somagoni, Jagan M. Panakanti, Pavan K. Ega, Chandra M. Yamsani, Madhusudan R.
author_sort	Sunil, R.
title	Influence of cellulose derivatives and natural polymers on in vitro release kinetics of metoprolol succinate from extended release matrix tablets
title_short	Influence of cellulose derivatives and natural polymers on in vitro release kinetics of metoprolol succinate from extended release matrix tablets
title_full	Influence of cellulose derivatives and natural polymers on in vitro release kinetics of metoprolol succinate from extended release matrix tablets
title_fullStr	Influence of cellulose derivatives and natural polymers on in vitro release kinetics of metoprolol succinate from extended release matrix tablets
title_full_unstemmed	Influence of cellulose derivatives and natural polymers on in vitro release kinetics of metoprolol succinate from extended release matrix tablets
title_sort	influence of cellulose derivatives and natural polymers on in vitro release kinetics of metoprolol succinate from extended release matrix tablets
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8262 http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_4.pdf
work_keys_str_mv	AT sunilr influenceofcellulosederivativesandnaturalpolymersoninvitroreleasekineticsofmetoprololsuccinatefromextendedreleasematrixtablets AT somagonijaganm influenceofcellulosederivativesandnaturalpolymersoninvitroreleasekineticsofmetoprololsuccinatefromextendedreleasematrixtablets AT panakantipavank influenceofcellulosederivativesandnaturalpolymersoninvitroreleasekineticsofmetoprololsuccinatefromextendedreleasematrixtablets AT egachandram influenceofcellulosederivativesandnaturalpolymersoninvitroreleasekineticsofmetoprololsuccinatefromextendedreleasematrixtablets AT yamsanimadhusudanr influenceofcellulosederivativesandnaturalpolymersoninvitroreleasekineticsofmetoprololsuccinatefromextendedreleasematrixtablets
bdutipo_str	Repositorios
_version_	1764820488453881861

Influence of cellulose derivatives and natural polymers on in vitro release kinetics of metoprolol succinate from extended release matrix tablets

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