Increased male offspring's risk of metabolic-neuroendocrine dysfunction and overweight after fructose-rich diet intake by the lactating mother

An adverse endogenous environment during early life predisposes the organism to develop metabolic disorders. We evaluated the impact of intake of an iso-caloric fructose rich diet (FRD) by lactating mothers (LM) on several metabolic functions of their male offspring. On postnatal d 1, ad libitum eat...

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Autores principales: Alzamendi, Ana, Castrogiovanni, Daniel, Gaillard, Rolf C., Spinedi, Eduardo, Giovambattista, Andrés
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Ciencias Médicas
Bioquímica
adipocytokine
carbohydrate diet
STAT3 protein
body weight
lactation
male
metabolic disorder
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/82602
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-82602
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Bioquímica
adipocytokine
carbohydrate diet
STAT3 protein
body weight
lactation
male
metabolic disorder
spellingShingle Ciencias Médicas
Bioquímica
adipocytokine
carbohydrate diet
STAT3 protein
body weight
lactation
male
metabolic disorder
Alzamendi, Ana
Castrogiovanni, Daniel
Gaillard, Rolf C.
Spinedi, Eduardo
Giovambattista, Andrés
Increased male offspring's risk of metabolic-neuroendocrine dysfunction and overweight after fructose-rich diet intake by the lactating mother
topic_facet Ciencias Médicas
Bioquímica
adipocytokine
carbohydrate diet
STAT3 protein
body weight
lactation
male
metabolic disorder
description An adverse endogenous environment during early life predisposes the organism to develop metabolic disorders. We evaluated the impact of intake of an iso-caloric fructose rich diet (FRD) by lactating mothers (LM) on several metabolic functions of their male offspring. On postnatal d 1, ad libitum eating, lactating Sprague-Dawley rats received either 10% F (wt/vol; FRD-LM) or tap water (controls, CTR-LM) to drink throughout lactation. Weaned male offspring were fed ad libitum a normal diet, and body weight (BW) and food intake were registered until experimentation (60 d of age). Basal circulating levels of metabolic markers were evaluated. Both iv glucose tolerance and hypothalamic leptin sensitivity tests were performed. The hypothalamus was dissected for isolation of total RNA and Western blot analysis. Retroperitoneal (RP) adipose tissue was dissected and either kept frozen for gene analysis or digested to isolate adipocytes or for histological studies. FRD rats showed increased BW and decreased hypothalamic sensitivity to exogenous leptin, enhanced food intake (between 49-60 d), and decreased hypothalamic expression of several anorexigenic signals. FRD rats developed increased insulin and leptin peripheral levels and decreased adiponectinemia; although FRD rats normally tolerated glucose excess, it was associated with enhanced insulin secretion. FRD RP adipocytes were enlarged and spontaneously released high leptin, although they were less sensitive to insulin-induced leptin release. Accordingly, RP fat leptin gene expression was high in FRD rats. Excessive fructose consumption by lactating mothers resulted in deep neuroendocrine-metabolic disorders of their male offspring, probably enhancing the susceptibility to develop overweight/obesity during adult life.
format Articulo
Articulo
author Alzamendi, Ana
Castrogiovanni, Daniel
Gaillard, Rolf C.
Spinedi, Eduardo
Giovambattista, Andrés
author_facet Alzamendi, Ana
Castrogiovanni, Daniel
Gaillard, Rolf C.
Spinedi, Eduardo
Giovambattista, Andrés
author_sort Alzamendi, Ana
title Increased male offspring's risk of metabolic-neuroendocrine dysfunction and overweight after fructose-rich diet intake by the lactating mother
title_short Increased male offspring's risk of metabolic-neuroendocrine dysfunction and overweight after fructose-rich diet intake by the lactating mother
title_full Increased male offspring's risk of metabolic-neuroendocrine dysfunction and overweight after fructose-rich diet intake by the lactating mother
title_fullStr Increased male offspring's risk of metabolic-neuroendocrine dysfunction and overweight after fructose-rich diet intake by the lactating mother
title_full_unstemmed Increased male offspring's risk of metabolic-neuroendocrine dysfunction and overweight after fructose-rich diet intake by the lactating mother
title_sort increased male offspring's risk of metabolic-neuroendocrine dysfunction and overweight after fructose-rich diet intake by the lactating mother
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/82602
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