Didanosine-loaded chitosan microspheres: optimization of fabrication process

Didanosine (ddI) is an important drug in the AIDS therapy. However, to overcome the instability of ddI in acid medium, the tablets have a large amount of buffer that can lead to side effects such as diarrhea and kidney problems. Microencapsulation of ddI can reduce the excessive use of buffers. In t...

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Autores principales: Silva, Classius F. da, Severino, Patrícia, Martins, Fernanda, Santana, Maria H. A.
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
chitosan; ddI; didanosine; ionotropic gelation
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8258
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_11.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8258
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
chitosan; ddI; didanosine; ionotropic gelation
spellingShingle Farmacia
chitosan; ddI; didanosine; ionotropic gelation
Silva, Classius F. da
Severino, Patrícia
Martins, Fernanda
Santana, Maria H. A.
Didanosine-loaded chitosan microspheres: optimization of fabrication process
topic_facet Farmacia
chitosan; ddI; didanosine; ionotropic gelation
description Didanosine (ddI) is an important drug in the AIDS therapy. However, to overcome the instability of ddI in acid medium, the tablets have a large amount of buffer that can lead to side effects such as diarrhea and kidney problems. Microencapsulation of ddI can reduce the excessive use of buffers. In this work we used the ionotropic gelation technique in the preparation of chitosan microspheres. The microspheres were characterized according to the incorporation efficiency, loading capacity, degree of swelling, permeability and morphology. The best results were obtained for 10 g of chitosan/g of sodium tripolyphosphate. Subsequently, changes were carried out in the agitation system in order to optimize it. Such changes were able to improve the incorporation efficiency as well as reduce the energy consumption of the system.
format Articulo
Comunicacion
author Silva, Classius F. da
Severino, Patrícia
Martins, Fernanda
Santana, Maria H. A.
author_facet Silva, Classius F. da
Severino, Patrícia
Martins, Fernanda
Santana, Maria H. A.
author_sort Silva, Classius F. da
title Didanosine-loaded chitosan microspheres: optimization of fabrication process
title_short Didanosine-loaded chitosan microspheres: optimization of fabrication process
title_full Didanosine-loaded chitosan microspheres: optimization of fabrication process
title_fullStr Didanosine-loaded chitosan microspheres: optimization of fabrication process
title_full_unstemmed Didanosine-loaded chitosan microspheres: optimization of fabrication process
title_sort didanosine-loaded chitosan microspheres: optimization of fabrication process
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8258
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_11.pdf
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AT severinopatricia didanosineloadedchitosanmicrospheresoptimizationoffabricationprocess
AT martinsfernanda didanosineloadedchitosanmicrospheresoptimizationoffabricationprocess
AT santanamariaha didanosineloadedchitosanmicrospheresoptimizationoffabricationprocess
bdutipo_str Repositorios
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