Pharmacokinetics of lansoprazole injection in peptic ulcer and healthy volunteers

The pharmacokinetics of lansoprazole after a single intravenous dose of 30 mg was determined in 10 healthy volunteers and 10 peptic ulcers patients. In this work, a liquid-liquid extraction and enrichment method with RP-HPLC determination route was taken with high sensitivity and low limit detection...

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Autores principales:	Yang, Dongzhi, Gao, Yuanyuan, Jiang, Xianglan, Dong, Weifeng, Tang, Daoquan
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia high-performance liquid chromatography; lansoprazole; peptic ulcers; pharmacokinetics Técnicas de Química Analítica Enfermedades Gastrointestinales Agentes Gastrointestinales Fenómenos Farmacológicos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8253 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_6.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8253
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia high-performance liquid chromatography; lansoprazole; peptic ulcers; pharmacokinetics Técnicas de Química Analítica Enfermedades Gastrointestinales Agentes Gastrointestinales Fenómenos Farmacológicos
spellingShingle	Farmacia high-performance liquid chromatography; lansoprazole; peptic ulcers; pharmacokinetics Técnicas de Química Analítica Enfermedades Gastrointestinales Agentes Gastrointestinales Fenómenos Farmacológicos Yang, Dongzhi Gao, Yuanyuan Jiang, Xianglan Dong, Weifeng Tang, Daoquan Pharmacokinetics of lansoprazole injection in peptic ulcer and healthy volunteers
topic_facet	Farmacia high-performance liquid chromatography; lansoprazole; peptic ulcers; pharmacokinetics Técnicas de Química Analítica Enfermedades Gastrointestinales Agentes Gastrointestinales Fenómenos Farmacológicos
description	The pharmacokinetics of lansoprazole after a single intravenous dose of 30 mg was determined in 10 healthy volunteers and 10 peptic ulcers patients. In this work, a liquid-liquid extraction and enrichment method with RP-HPLC determination route was taken with high sensitivity and low limit detection of 5 ng/mL. The concentration-time curves in the two groups were best fitted to a two-compartment model, but their main kinetic parameters were remarkably different between healthy and ulcers volunteers. The mean maximum plasma concentration (C<sub>max</sub> ) and area under the curve (AUC<sub>0t</sub> ) were increased from 975.8 ng/mL to 1298.7 ng/mL and from 1439 ng·h/mL to 2301 ng·h/mL, respectively, and peak time (t<sub>max</sub> ) decreased from 0.36 h to 0.26 h. Meanwhile, the half life (t<sub>1/2</sub> ) prolonged from 2.25 h to 2.91 h and the clearance (CL) reduced from 20.04 L/h to 13.96 L/h. That variability of lansoprazole pharmakinetic parameter indicates that ulcers have significant effect on its metabolic process.
format	Articulo Comunicacion
author	Yang, Dongzhi Gao, Yuanyuan Jiang, Xianglan Dong, Weifeng Tang, Daoquan
author_facet	Yang, Dongzhi Gao, Yuanyuan Jiang, Xianglan Dong, Weifeng Tang, Daoquan
author_sort	Yang, Dongzhi
title	Pharmacokinetics of lansoprazole injection in peptic ulcer and healthy volunteers
title_short	Pharmacokinetics of lansoprazole injection in peptic ulcer and healthy volunteers
title_full	Pharmacokinetics of lansoprazole injection in peptic ulcer and healthy volunteers
title_fullStr	Pharmacokinetics of lansoprazole injection in peptic ulcer and healthy volunteers
title_full_unstemmed	Pharmacokinetics of lansoprazole injection in peptic ulcer and healthy volunteers
title_sort	pharmacokinetics of lansoprazole injection in peptic ulcer and healthy volunteers
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8253 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_6.pdf
work_keys_str_mv	AT yangdongzhi pharmacokineticsoflansoprazoleinjectioninpepticulcerandhealthyvolunteers AT gaoyuanyuan pharmacokineticsoflansoprazoleinjectioninpepticulcerandhealthyvolunteers AT jiangxianglan pharmacokineticsoflansoprazoleinjectioninpepticulcerandhealthyvolunteers AT dongweifeng pharmacokineticsoflansoprazoleinjectioninpepticulcerandhealthyvolunteers AT tangdaoquan pharmacokineticsoflansoprazoleinjectioninpepticulcerandhealthyvolunteers
bdutipo_str	Repositorios
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Pharmacokinetics of lansoprazole injection in peptic ulcer and healthy volunteers

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