Fabrication of novel gastro-retentive Floating microcapsules by utilizing a combination of HPMC and EC and their physicochemical assessment

The project was aimed to develop floating microcapsules (FMs) using combination of a hydrophobic (ethyl cellulose, EC) and hydrophilic polymer (hydroxy propyl methyl cellulose, HPMC), and to evaluate them. An easy and novel phase separation method was adopted to prepare FMs. Chloroform and paraffin...

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Autores principales:	Aamir, Muhammad N., Ahmad, Mahmood, Khan, Shujaat A., Akhtar, Naveed, Murtaza, Ghulam, Akhtar, Muhammad, Rasool, Fatima
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia floating microcapsules; non-solvent addition; polymers combination; tramadol Cápsulas Evaluación de Medicamentos Polímeros
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8252 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_5.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8252
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia floating microcapsules; non-solvent addition; polymers combination; tramadol Cápsulas Evaluación de Medicamentos Polímeros
spellingShingle	Farmacia floating microcapsules; non-solvent addition; polymers combination; tramadol Cápsulas Evaluación de Medicamentos Polímeros Aamir, Muhammad N. Ahmad, Mahmood Khan, Shujaat A. Akhtar, Naveed Murtaza, Ghulam Akhtar, Muhammad Rasool, Fatima Fabrication of novel gastro-retentive Floating microcapsules by utilizing a combination of HPMC and EC and their physicochemical assessment
topic_facet	Farmacia floating microcapsules; non-solvent addition; polymers combination; tramadol Cápsulas Evaluación de Medicamentos Polímeros
description	The project was aimed to develop floating microcapsules (FMs) using combination of a hydrophobic (ethyl cellulose, EC) and hydrophilic polymer (hydroxy propyl methyl cellulose, HPMC), and to evaluate them. An easy and novel phase separation method was adopted to prepare FMs. Chloroform and paraffin oil were employed as solvent and non-solvent respectively. Five kinetic models were applied to assess and describe the mechanism and pattern of tramadol hydrochloride (TmH) release from FMs and they were subjected to FTIR and XRD to evaluate TmH-HPMC-EC interaction. As EC concentration was increased the retardation in drug release, improvement in flow characteristics and decrease in floating time were observed. Kinetics of drug release was followed by Korsmeyer-Peppas kinetic model. It was concluded that the floating microcapsules of TmH can be produced using phase separation method and they have no drug-polymer interaction. The accelerated stability studies also ensured the physicochemical integrity of FMs.
format	Articulo Comunicacion
author	Aamir, Muhammad N. Ahmad, Mahmood Khan, Shujaat A. Akhtar, Naveed Murtaza, Ghulam Akhtar, Muhammad Rasool, Fatima
author_facet	Aamir, Muhammad N. Ahmad, Mahmood Khan, Shujaat A. Akhtar, Naveed Murtaza, Ghulam Akhtar, Muhammad Rasool, Fatima
author_sort	Aamir, Muhammad N.
title	Fabrication of novel gastro-retentive Floating microcapsules by utilizing a combination of HPMC and EC and their physicochemical assessment
title_short	Fabrication of novel gastro-retentive Floating microcapsules by utilizing a combination of HPMC and EC and their physicochemical assessment
title_full	Fabrication of novel gastro-retentive Floating microcapsules by utilizing a combination of HPMC and EC and their physicochemical assessment
title_fullStr	Fabrication of novel gastro-retentive Floating microcapsules by utilizing a combination of HPMC and EC and their physicochemical assessment
title_full_unstemmed	Fabrication of novel gastro-retentive Floating microcapsules by utilizing a combination of HPMC and EC and their physicochemical assessment
title_sort	fabrication of novel gastro-retentive floating microcapsules by utilizing a combination of hpmc and ec and their physicochemical assessment
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8252 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_5.pdf
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Fabrication of novel gastro-retentive Floating microcapsules by utilizing a combination of HPMC and EC and their physicochemical assessment

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