Effect of Ashwagandha and Aloe vera pretreatment on intestinal transport of buspirone across rat intestine

The transport of buspirone across rat intestine (duodenum, jejunum, ileum and colon) was studied by using the non-everted sac method. Rats were pretreated with ashwagandha (Withania somnifera) and Aloe vera juice for 7 days. The rats were sacrificed by using anesthetic ether, the intestinal segments...

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Detalles Bibliográficos
Autores principales: Yamsani, Shravan K., Devandla, Adukondalu, Yamsani, Vamshi V., Athukuri, Bhargavilatha, Gannu, Ramesh, Palem, Chinna R., Rao, Yamsani Madhusudan, Manda, Sarangapani
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Cromatografia líquida de alta eficiencia
aloe vera; ashwagandha; buspirone; CYP3A; noneverted sac; p-glycoprotein, withania somnifera
Extractos Vegetales
Agentes Ansiolíticos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8251
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8251
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Cromatografia líquida de alta eficiencia
aloe vera; ashwagandha; buspirone; CYP3A; noneverted sac; p-glycoprotein, withania somnifera
Extractos Vegetales
Agentes Ansiolíticos
spellingShingle Farmacia
Cromatografia líquida de alta eficiencia
aloe vera; ashwagandha; buspirone; CYP3A; noneverted sac; p-glycoprotein, withania somnifera
Extractos Vegetales
Agentes Ansiolíticos
Yamsani, Shravan K.
Devandla, Adukondalu
Yamsani, Vamshi V.
Athukuri, Bhargavilatha
Gannu, Ramesh
Palem, Chinna R.
Rao, Yamsani Madhusudan
Manda, Sarangapani
Effect of Ashwagandha and Aloe vera pretreatment on intestinal transport of buspirone across rat intestine
topic_facet Farmacia
Cromatografia líquida de alta eficiencia
aloe vera; ashwagandha; buspirone; CYP3A; noneverted sac; p-glycoprotein, withania somnifera
Extractos Vegetales
Agentes Ansiolíticos
description The transport of buspirone across rat intestine (duodenum, jejunum, ileum and colon) was studied by using the non-everted sac method. Rats were pretreated with ashwagandha (Withania somnifera) and Aloe vera juice for 7 days. The rats were sacrificed by using anesthetic ether, the intestinal segments were isolated and used for the studies. The probe drug (buspirone) solution was placed in the isolated intestinal sac. Samples were collected at preset time points and replaced with fresh buffer. The drug content in the samples was estimated using high performance liquid chromatography method. Control experiments were also performed. The results reveal that there was a significant (p < 0.05) difference compared to control, in the transport of buspirone from the intestinal sacs which were pretreated with ashwagandha and Aloe vera juice. It suggests that both ashwagandha and Aloe vera might be acting by inhibiting the transporters and enzymes which are responsible for transport/metabolism of buspirone.
format Articulo
Comunicacion
author Yamsani, Shravan K.
Devandla, Adukondalu
Yamsani, Vamshi V.
Athukuri, Bhargavilatha
Gannu, Ramesh
Palem, Chinna R.
Rao, Yamsani Madhusudan
Manda, Sarangapani
author_facet Yamsani, Shravan K.
Devandla, Adukondalu
Yamsani, Vamshi V.
Athukuri, Bhargavilatha
Gannu, Ramesh
Palem, Chinna R.
Rao, Yamsani Madhusudan
Manda, Sarangapani
author_sort Yamsani, Shravan K.
title Effect of Ashwagandha and Aloe vera pretreatment on intestinal transport of buspirone across rat intestine
title_short Effect of Ashwagandha and Aloe vera pretreatment on intestinal transport of buspirone across rat intestine
title_full Effect of Ashwagandha and Aloe vera pretreatment on intestinal transport of buspirone across rat intestine
title_fullStr Effect of Ashwagandha and Aloe vera pretreatment on intestinal transport of buspirone across rat intestine
title_full_unstemmed Effect of Ashwagandha and Aloe vera pretreatment on intestinal transport of buspirone across rat intestine
title_sort effect of ashwagandha and aloe vera pretreatment on intestinal transport of buspirone across rat intestine
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8251
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_4.pdf
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