Diclofenac quantification: analytical attributes of a spectrophotometric method

An spectrophotometric UV-visible technique used to quantify diclofenac and its application to pharmaceutical preparations is described, based on diclofenac oxidation by Fe(III) in the presence of ophenanthroline. The formation of tris (o-phenanthroline)-Fe(II) complex (ferroin) upon diclofenac react...

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Detalles Bibliográficos
Autores principales:	Monzón, Celina M., Delfino, Mario R., Sarno, María del C., Delfino, Mario R. (h)
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia diclofenac; quantification; spectrophotometry; tablets Técnicas de Química Analítica Preparaciones Farmacéuticas Agentes Antiinflamatorios no Esteroides
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8250 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_3.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia diclofenac; quantification; spectrophotometry; tablets Técnicas de Química Analítica Preparaciones Farmacéuticas Agentes Antiinflamatorios no Esteroides
spellingShingle	Farmacia diclofenac; quantification; spectrophotometry; tablets Técnicas de Química Analítica Preparaciones Farmacéuticas Agentes Antiinflamatorios no Esteroides Monzón, Celina M. Delfino, Mario R. Sarno, María del C. Delfino, Mario R. (h) Diclofenac quantification: analytical attributes of a spectrophotometric method
topic_facet	Farmacia diclofenac; quantification; spectrophotometry; tablets Técnicas de Química Analítica Preparaciones Farmacéuticas Agentes Antiinflamatorios no Esteroides
description	An spectrophotometric UV-visible technique used to quantify diclofenac and its application to pharmaceutical preparations is described, based on diclofenac oxidation by Fe(III) in the presence of ophenanthroline. The formation of tris (o-phenanthroline)-Fe(II) complex (ferroin) upon diclofenac reaction was investigated. Absorbance of ferroin complex was measured at 506 nm. This method was tested on 50 mg tablets. Operating with placebos, it was found that excipients do not interfere with the determination. A good linearity was found [y = (0.0294 ± 0.0041)x + (0.1326 ± 0.0559)] with r2 = 0.9982, calibration curve showed a linear range from 5-15 μg/mL of diclofenac. The proposed method was found to be highly precise, having a relative standard deviation (CV) below 2.0 % in repeatability and intermediate precision studies. Accuracy: based on the average recovery of known amounts of drug in placebo was 98.07-101.97 % values that fall within the requirements set by USP and ANMAT (98.0-102.0 %). This method was found to be simple, rapid, specific, linear, reliable and robust, allowing the determination without preliminary extraction procedures.
format	Articulo Comunicacion
author	Monzón, Celina M. Delfino, Mario R. Sarno, María del C. Delfino, Mario R. (h)
author_facet	Monzón, Celina M. Delfino, Mario R. Sarno, María del C. Delfino, Mario R. (h)
author_sort	Monzón, Celina M.
title	Diclofenac quantification: analytical attributes of a spectrophotometric method
title_short	Diclofenac quantification: analytical attributes of a spectrophotometric method
title_full	Diclofenac quantification: analytical attributes of a spectrophotometric method
title_fullStr	Diclofenac quantification: analytical attributes of a spectrophotometric method
title_full_unstemmed	Diclofenac quantification: analytical attributes of a spectrophotometric method
title_sort	diclofenac quantification: analytical attributes of a spectrophotometric method
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8250 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_3.pdf
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bdutipo_str	Repositorios
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Diclofenac quantification: analytical attributes of a spectrophotometric method

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