Potential role of the intestinal microbiota of the mother in neonatal immune education

Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bact...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Donnet Hughes, Anne, Pérez, Pablo Fernando, Doré, Joël, Leclerc, Marion, Levenez, Florence, Benyacoub, Jalil, Serrant, Patrick, Segura Roggero, Iris, Schiffrin, Eduardo J.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Ciencias Exactas
Bacterial translocation
Breast milk
Lactation
Microbiota
Neonatal immunity
Pregnancy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/82485
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-82485
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Bacterial translocation
Breast milk
Lactation
Microbiota
Neonatal immunity
Pregnancy
spellingShingle Ciencias Exactas
Bacterial translocation
Breast milk
Lactation
Microbiota
Neonatal immunity
Pregnancy
Donnet Hughes, Anne
Pérez, Pablo Fernando
Doré, Joël
Leclerc, Marion
Levenez, Florence
Benyacoub, Jalil
Serrant, Patrick
Segura Roggero, Iris
Schiffrin, Eduardo J.
Potential role of the intestinal microbiota of the mother in neonatal immune education
topic_facet Ciencias Exactas
Bacterial translocation
Breast milk
Lactation
Microbiota
Neonatal immunity
Pregnancy
description Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer's patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns.
format Articulo
Articulo
author Donnet Hughes, Anne
Pérez, Pablo Fernando
Doré, Joël
Leclerc, Marion
Levenez, Florence
Benyacoub, Jalil
Serrant, Patrick
Segura Roggero, Iris
Schiffrin, Eduardo J.
author_facet Donnet Hughes, Anne
Pérez, Pablo Fernando
Doré, Joël
Leclerc, Marion
Levenez, Florence
Benyacoub, Jalil
Serrant, Patrick
Segura Roggero, Iris
Schiffrin, Eduardo J.
author_sort Donnet Hughes, Anne
title Potential role of the intestinal microbiota of the mother in neonatal immune education
title_short Potential role of the intestinal microbiota of the mother in neonatal immune education
title_full Potential role of the intestinal microbiota of the mother in neonatal immune education
title_fullStr Potential role of the intestinal microbiota of the mother in neonatal immune education
title_full_unstemmed Potential role of the intestinal microbiota of the mother in neonatal immune education
title_sort potential role of the intestinal microbiota of the mother in neonatal immune education
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/82485
work_keys_str_mv AT donnethughesanne potentialroleoftheintestinalmicrobiotaofthemotherinneonatalimmuneeducation
AT perezpablofernando potentialroleoftheintestinalmicrobiotaofthemotherinneonatalimmuneeducation
AT dorejoel potentialroleoftheintestinalmicrobiotaofthemotherinneonatalimmuneeducation
AT leclercmarion potentialroleoftheintestinalmicrobiotaofthemotherinneonatalimmuneeducation
AT levenezflorence potentialroleoftheintestinalmicrobiotaofthemotherinneonatalimmuneeducation
AT benyacoubjalil potentialroleoftheintestinalmicrobiotaofthemotherinneonatalimmuneeducation
AT serrantpatrick potentialroleoftheintestinalmicrobiotaofthemotherinneonatalimmuneeducation
AT seguraroggeroiris potentialroleoftheintestinalmicrobiotaofthemotherinneonatalimmuneeducation
AT schiffrineduardoj potentialroleoftheintestinalmicrobiotaofthemotherinneonatalimmuneeducation
bdutipo_str Repositorios
_version_ 1764820488328052740

Ejemplares similares