The behavior of the hydrophobic effect under pressure and protein denaturation

It is well known that proteins denature under high pressure. The mechanism that underlies such a process is still not clearly understood, however, giving way to controversial interpretations. Using molecular dynamics simulation on systems that may be regarded experimentally as limiting examples of t...

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Autores principales: Grigera, José Raúl, McCarthy, Andrés Norman
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Física
Proteína
Interacciones Hidrofóbicas e Hidrofílicas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/82432
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-82432
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Física
Proteína
Interacciones Hidrofóbicas e Hidrofílicas
spellingShingle Física
Proteína
Interacciones Hidrofóbicas e Hidrofílicas
Grigera, José Raúl
McCarthy, Andrés Norman
The behavior of the hydrophobic effect under pressure and protein denaturation
topic_facet Física
Proteína
Interacciones Hidrofóbicas e Hidrofílicas
description It is well known that proteins denature under high pressure. The mechanism that underlies such a process is still not clearly understood, however, giving way to controversial interpretations. Using molecular dynamics simulation on systems that may be regarded experimentally as limiting examples of the effect of high pressure on globular proteins, such as lysozyme and apomyoglobin, we have effectively reproduced such similarities and differences in behavior as are interpreted from experiment. From the analysis of such data, we explain the experimental evidence at hand through the effect of pressure on the change of water structure, and hence the weakening of the hydrophobic effect that is known to be the main driving force in protein folding.
format Articulo
Articulo
author Grigera, José Raúl
McCarthy, Andrés Norman
author_facet Grigera, José Raúl
McCarthy, Andrés Norman
author_sort Grigera, José Raúl
title The behavior of the hydrophobic effect under pressure and protein denaturation
title_short The behavior of the hydrophobic effect under pressure and protein denaturation
title_full The behavior of the hydrophobic effect under pressure and protein denaturation
title_fullStr The behavior of the hydrophobic effect under pressure and protein denaturation
title_full_unstemmed The behavior of the hydrophobic effect under pressure and protein denaturation
title_sort behavior of the hydrophobic effect under pressure and protein denaturation
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/82432
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