Formulation and characterization of rifabutin loaded floating gellan gum beads

Rifabutin loaded floating gellan gum beads were prepared by Ca++ induced ionotropic gelation in acidic medium by drop wise addition of gellan gum dispersion containing drug and gas-generating agent. The prepared beads were evaluated for in vitro characterization and in vivo Helicobacter pylori clear...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Verma, Anurag, Pandit, Jayant K.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Rifamicinas floating beads; gellan gum; helicobacter pylori; incorporation efficiency; rifabutin Sistemas de Liberación de Medicamentos Bacterias
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8243 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_19.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8243
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Rifamicinas floating beads; gellan gum; helicobacter pylori; incorporation efficiency; rifabutin Sistemas de Liberación de Medicamentos Bacterias
spellingShingle	Farmacia Rifamicinas floating beads; gellan gum; helicobacter pylori; incorporation efficiency; rifabutin Sistemas de Liberación de Medicamentos Bacterias Verma, Anurag Pandit, Jayant K. Formulation and characterization of rifabutin loaded floating gellan gum beads
topic_facet	Farmacia Rifamicinas floating beads; gellan gum; helicobacter pylori; incorporation efficiency; rifabutin Sistemas de Liberación de Medicamentos Bacterias
description	Rifabutin loaded floating gellan gum beads were prepared by Ca++ induced ionotropic gelation in acidic medium by drop wise addition of gellan gum dispersion containing drug and gas-generating agent. The prepared beads were evaluated for in vitro characterization and in vivo Helicobacter pylori clearance efficiency following repeated oral administration to H. pylori infected albino rats. Live cell staining of stomach homogenates of H. pylori infected animals treated with rifabutin showed pronounced anti H. pylori activity. Our results suggested that the floating gellan gum beads may be used for a potential oral stomach-specific release system to treat stomach-specific infections like multi-drug resistant H. pylori infection.
format	Articulo Articulo
author	Verma, Anurag Pandit, Jayant K.
author_facet	Verma, Anurag Pandit, Jayant K.
author_sort	Verma, Anurag
title	Formulation and characterization of rifabutin loaded floating gellan gum beads
title_short	Formulation and characterization of rifabutin loaded floating gellan gum beads
title_full	Formulation and characterization of rifabutin loaded floating gellan gum beads
title_fullStr	Formulation and characterization of rifabutin loaded floating gellan gum beads
title_full_unstemmed	Formulation and characterization of rifabutin loaded floating gellan gum beads
title_sort	formulation and characterization of rifabutin loaded floating gellan gum beads
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8243 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_19.pdf
work_keys_str_mv	AT vermaanurag formulationandcharacterizationofrifabutinloadedfloatinggellangumbeads AT panditjayantk formulationandcharacterizationofrifabutinloadedfloatinggellangumbeads
bdutipo_str	Repositorios
_version_	1764820488272478210

Formulation and characterization of rifabutin loaded floating gellan gum beads

Ejemplares similares